haf-3 ABC transmembrane type-1 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: haf-3
Official Full Name: ABC transmembrane type-1 domain-containing protein
Primary source: WormBase:WBGene00001813
Locus tag: CELE_F57A10.3
See related: AllianceGenome:WB:WBGene00001813
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in intestine and spermatheca. Orthologous to human ABCB10 (ATP binding cassette subfamily B member 10). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See haf-3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 14

Sequence:: Chromosome: V; NC_003283.11 (15760455..15766172, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F57A10.3 (e-PCR)
- UniSTS:311889

F57A10.2 (e-PCR)
- UniSTS:316826

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in response to chemical	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ABC transmembrane type-1 domain-containing protein

NP_506927.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

15760455..15766172 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074526.8 → NP_506927.2 ABC transmembrane type-1 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506927.2

Status: REVIEWED

UniProtKB/TrEMBL

O17895

Conserved Domains (3) summary

COG1132
Location:70 → 657

MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]

pfam00664
Location:96 → 366

ABC_membrane; ABC transporter transmembrane region

cl21455
Location:415 → 656

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases