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slc-25A29 Mitochondrial carnitine/acylcarnitine carrier protein CACL [ Caenorhabditis elegans ]

Gene ID: 179969, updated on 9-Dec-2024

Summary

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Official Symbol
slc-25A29
Official Full Name
Mitochondrial carnitine/acylcarnitine carrier protein CACL
Primary source
WormBase:WBGene00008320
Locus tag
CELE_C54G10.4
See related
AllianceGenome:WB:WBGene00008320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable high-affinity L-arginine transmembrane transporter activity and high-affinity lysine transmembrane transporter activity. Predicted to be involved in mitochondrial L-ornithine transmembrane transport. Predicted to be located in membrane. Predicted to be active in mitochondrion. Orthologous to human SLC25A29 (solute carrier family 25 member 29). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See slc-25A29 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (14653489..14658175, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Replication factor C subunit 1 Neighboring gene ATP-binding cassette sub-family D member 4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class H Neighboring gene Secreted protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditiselegans. Tang R, et al. J Genet Genomics, 2020 Mar 20. PMID 32305173
  2. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

prim_transcript

  • Loc: c14656636-14656500 standard_name = C54G10.6.1

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables high-affinity L-arginine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables high-affinity lysine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in L-arginine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial L-ornithine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Mitochondrial carnitine/acylcarnitine carrier protein CACL
NP_001294735.1
  • Confirmed by transcript evidence
NP_001379141.1
  • Confirmed by transcript evidence
NP_872134.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    14653489..14658175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392659.1 → NP_001379141.1  Mitochondrial carnitine/acylcarnitine carrier protein CACL [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18844
    Conserved Domains (1) summary
    pfam00153
    Location:91 → 186
    Mito_carr; Mitochondrial carrier protein

  2. NM_182334.4 → NP_872134.1  Mitochondrial carnitine/acylcarnitine carrier protein CACL [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_872134.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I4M0
    Conserved Domains (2) summary
    PTZ00169
    Location:1 → 258
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:91 → 186
    Mito_carr; Mitochondrial carrier protein

  3. NM_001307806.4 → NP_001294735.1  Mitochondrial carnitine/acylcarnitine carrier protein CACL [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294735.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M1ZJU4
    Conserved Domains (2) summary
    PTZ00169
    Location:1 → 258
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:91 → 186
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
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