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Neb nebulin [ Mus musculus (house mouse) ]

Gene ID: 17996, updated on 27-Nov-2024

Summary

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Official Symbol
Nebprovided by MGI
Official Full Name
nebulinprovided by MGI
Primary source
MGI:MGI:97292
See related
Ensembl:ENSMUSG00000026950 AllianceGenome:MGI:97292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in cardiac muscle thin filament assembly. Predicted to act upstream of or within regulation of actin filament length and sarcomere organization. Located in Z disc. Is expressed in hindlimb muscle; palatal shelf; and trunk dermomyotome. Used to study nemaline myopathy 2. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-6 and nemaline myopathy 2. Orthologous to human NEB (nebulin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in mammary gland adult (RPKM 5.3), limb E14.5 (RPKM 2.8) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Neb in Genome Data Viewer
Location:
2 C1.1; 2 29.98 cM
Exon count:
166
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (52026652..52228810, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (52136640..52338798, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor alpha induced protein 6 Neighboring gene STARR-seq mESC enhancer starr_04477 Neighboring gene replication timing regulatory factor 1 Neighboring gene STARR-seq mESC enhancer starr_04479 Neighboring gene RIKEN cDNA 4930573O16 gene Neighboring gene STARR-seq mESC enhancer starr_04480 Neighboring gene predicted gene 13521 Neighboring gene predicted gene 13522

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential splicing of the large sarcomeric protein nebulin during skeletal muscle development. Buck D, et al. J Struct Biol, 2010 May. PMID 20176113, Free PMC Article
  2. Nebulin stiffens the thin filament and augments cross-bridge interaction in skeletal muscle. Kiss B, et al. Proc Natl Acad Sci U S A, 2018 Oct 9. PMID 30249654, Free PMC Article
  3. Muscle weakness in respiratory and peripheral skeletal muscles in a mouse model for nebulin-based nemaline myopathy. Joureau B, et al. Neuromuscul Disord, 2017 Jan. PMID 27890461, Free PMC Article
  4. Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy. Li F, et al. Hum Mol Genet, 2015 Sep 15. PMID 26123491, Free PMC Article
  5. cDNA cloning of mouse nebulin. Evidence that the nebulin-coding sequence is highly conserved among vertebrates. Zhang JQ, et al. Eur J Biochem, 1996 Aug 1. PMID 8774733

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aberrations in Energetic Metabolism and Stress-Related Pathways Contribute to Pathophysiology in the Neb Conditional Knockout Mouse Model of Nemaline Myopathy.
    Title: Aberrations in Energetic Metabolism and Stress-Related Pathways Contribute to Pathophysiology in the Neb Conditional Knockout Mouse Model of Nemaline Myopathy.
  2. NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy.
    Title: NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy.
  3. Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin.
    Title: Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin.
  4. Bioinformatics Analysis and High-Throughput Sequencing to Identify Differentially Expressed Genes in Nebulin Gene (NEB) Mutations Mice.
    Title: Bioinformatics Analysis and High-Throughput Sequencing to Identify Differentially Expressed Genes in Nebulin Gene (NEB) Mutations Mice.
  5. Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb.
    Title: Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb.
  6. Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism.
    Title: Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism.
  7. Study found that adult nebulin-deficient mice displayed severe muscle atrophy and weakness in vivo related to a low nebulin content but an improved fatigue resistance due to a slower contractile phenotype.
    Title: In vivo characterization of skeletal muscle function in nebulin-deficient mice.
  8. To study the functions of nebulin's C-terminus, we generated a mouse model deleting the final two unique C-terminal domains, the serine-rich region (SRR) and the SH3 domain (NebDelta163-165).
    Title: Deleting nebulin's C-terminus reveals its importance to sarcomeric structure and function and is sufficient to invoke nemaline myopathy.
  9. Muscle fibers are weak in the absence of Neb, in particular when large tension develops, which may structurally damage the thin filament when Neb is absent.
    Title: Nebulin increases thin filament stiffness and force per cross-bridge in slow-twitch soleus muscle fibers.
  10. Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity
    Title: Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cardiac muscle thin filament assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of actin filament length TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within sarcomere organization TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
located_in contractile muscle fiber IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in striated muscle thin filament TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
nebulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010889.1 → NP_035019.1  nebulin

    Status: VALIDATED

    Source sequence(s)
    AL844571, AL845355
    Consensus CDS
    CCDS50584.1
    UniProtKB/TrEMBL
    A2AQA9, E9Q1W3
    Related
    ENSMUSP00000047763.6, ENSMUST00000036934.12
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7095 → 7152
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:1103 → 1129
    Nebulin; Nebulin repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    52026652..52228810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159260.1 → XP_036015153.1  nebulin isoform X34

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:3909 → 3939
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7188 → 7245
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:4886 → 4913
    Nebulin; Nebulin repeat

  2. XM_036159285.1 → XP_036015178.1  nebulin isoform X48

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:3666 → 3696
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:6945 → 7002
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:4643 → 4670
    Nebulin; Nebulin repeat

  3. XM_036159259.1 → XP_036015152.1  nebulin isoform X33

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:3909 → 3939
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7188 → 7245
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:4886 → 4913
    Nebulin; Nebulin repeat

  4. XM_036159258.1 → XP_036015151.1  nebulin isoform X32

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:3909 → 3939
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7188 → 7245
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:4886 → 4913
    Nebulin; Nebulin repeat

  5. XM_036159255.1 → XP_036015148.1  nebulin isoform X31

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:3909 → 3939
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7188 → 7245
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:4886 → 4913
    Nebulin; Nebulin repeat

  6. XM_036159284.1 → XP_036015177.1  nebulin isoform X47

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:3666 → 3696
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:6945 → 7002
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:4643 → 4670
    Nebulin; Nebulin repeat

  7. XM_036159275.1 → XP_036015168.1  nebulin isoform X43

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7142 → 7199
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  8. XM_036159276.1 → XP_036015169.1  nebulin isoform X44

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7142 → 7199
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  9. XM_036159273.1 → XP_036015166.1  nebulin isoform X42

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7146 → 7203
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  10. XM_036159271.1 → XP_036015164.1  nebulin isoform X41

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7146 → 7203
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  11. XM_036159248.1 → XP_036015141.1  nebulin isoform X30

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7208 → 7265
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  12. XM_036159214.1 → XP_036015107.1  nebulin isoform X11

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7394 → 7451
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  13. XM_036159277.1 → XP_036015170.1  nebulin isoform X45

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7141 → 7198
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  14. XM_036159279.1 → XP_036015172.1  nebulin isoform X46

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7141 → 7198
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  15. XM_036159235.1 → XP_036015128.1  nebulin isoform X25

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (4) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    PTZ00121
    Location:6434 → 6863
    PTZ00121; MAEBL; Provisional
    cd11933
    Location:7238 → 7295
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  16. XM_036159216.1 → XP_036015109.1  nebulin isoform X12

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7393 → 7450
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  17. XM_036159269.1 → XP_036015162.1  nebulin isoform X40

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (4) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    PTZ00121
    Location:6434 → 6971
    PTZ00121; MAEBL; Provisional
    cd11933
    Location:7148 → 7205
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  18. XM_036159268.1 → XP_036015161.1  nebulin isoform X39

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7148 → 7205
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  19. XM_036159265.1 → XP_036015158.1  nebulin isoform X37

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (4) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    PTZ00121
    Location:6434 → 6997
    PTZ00121; MAEBL; Provisional
    cd11933
    Location:7179 → 7236
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  20. XM_036159211.1 → XP_036015104.1  nebulin isoform X10

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (4) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    PTZ00121
    Location:6434 → 6976
    PTZ00121; MAEBL; Provisional
    cd11933
    Location:7396 → 7453
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  21. XM_036159242.1 → XP_036015135.1  nebulin isoform X29

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7214 → 7271
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  22. XM_036159266.1 → XP_036015159.1  nebulin isoform X38

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7152 → 7209
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  23. XM_036159264.1 → XP_036015157.1  nebulin isoform X36

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7183 → 7240
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  24. XM_036159262.1 → XP_036015155.1  nebulin isoform X35

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7183 → 7240
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  25. XM_036159236.1 → XP_036015129.1  nebulin isoform X26

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7214 → 7271
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  26. XM_036159228.1 → XP_036015121.1  nebulin isoform X21

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7245 → 7302
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  27. XM_036159200.1 → XP_036015093.1  nebulin isoform X6

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7400 → 7457
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  28. XM_036159239.1 → XP_036015132.1  nebulin isoform X28

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7214 → 7271
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  29. XM_036159233.1 → XP_036015126.1  nebulin isoform X23

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7245 → 7302
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  30. XM_036159238.1 → XP_036015131.1  nebulin isoform X27

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7214 → 7271
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  31. XM_036159231.1 → XP_036015124.1  nebulin isoform X22

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7245 → 7302
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  32. XM_036159227.1 → XP_036015120.1  nebulin isoform X19

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7276 → 7333
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  33. XM_036159226.1 → XP_036015119.1  nebulin isoform X18

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7307 → 7364
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  34. XM_036159220.1 → XP_036015113.1  nebulin isoform X16

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7338 → 7395
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  35. XM_036159198.1 → XP_036015091.1  nebulin isoform X5

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7400 → 7457
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  36. XM_036159234.1 → XP_036015127.1  nebulin isoform X24

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7245 → 7302
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  37. XM_017316181.2 → XP_017171670.1  nebulin isoform X15

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7338 → 7395
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5131 → 5157
    Nebulin; Nebulin repeat

  38. XM_036159217.1 → XP_036015110.1  nebulin isoform X13

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7369 → 7426
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  39. XM_036159196.1 → XP_036015089.1  nebulin isoform X3

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7400 → 7457
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  40. XM_036159197.1 → XP_036015090.1  nebulin isoform X4

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7400 → 7457
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  41. XM_036159218.1 → XP_036015111.1  nebulin isoform X14

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7369 → 7426
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  42. XM_036159203.1 → XP_036015096.1  nebulin isoform X7

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7400 → 7457
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  43. XM_036159208.1 → XP_036015101.1  nebulin isoform X8

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7400 → 7457
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  44. XM_036159192.1 → XP_036015085.1  nebulin isoform X1

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7431 → 7488
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  45. XM_006497760.2 → XP_006497823.1  nebulin isoform X20

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7276 → 7333
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5131 → 5157
    Nebulin; Nebulin repeat

  46. XM_036159210.1 → XP_036015103.1  nebulin isoform X9

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7400 → 7457
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  47. XM_006497749.2 → XP_006497812.1  nebulin isoform X17

    See identical proteins and their annotated locations for XP_006497812.1

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7338 → 7395
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5131 → 5157
    Nebulin; Nebulin repeat

  48. XM_036159195.1 → XP_036015088.1  nebulin isoform X2

    UniProtKB/TrEMBL
    A0A571BF46, A2AQA9
    Related
    ENSMUSP00000158760.2, ENSMUST00000238288.2
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7431 → 7488
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat

  49. XM_006497776.2 → XP_006497839.1  nebulin isoform X49

    UniProtKB/TrEMBL
    A0A571BF58, A2AQA9
    Related
    ENSMUSP00000158777.2, ENSMUST00000238749.2
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7466 → 7523
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5131 → 5157
    Nebulin; Nebulin repeat

  50. XM_036159194.1 → XP_036015087.1  nebulin isoform X1

    UniProtKB/TrEMBL
    A2AQA9
    Conserved Domains (3) summary
    smart00227
    Location:4152 → 4182
    NEBU; The Nebulin repeat is present also in Las1
    cd11933
    Location:7431 → 7488
    SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
    pfam00880
    Location:5129 → 5156
    Nebulin; Nebulin repeat
Nucleotide Protein Strain
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