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cyn-1 Peptidyl-prolyl cis-trans isomerase 1 [ Caenorhabditis elegans ]

Gene ID: 179936, updated on 4-Jan-2025

Summary

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Official Symbol
cyn-1
Official Full Name
Peptidyl-prolyl cis-trans isomerase 1
Primary source
WormBase:WBGene00000877
Locus tag
CELE_Y49A3A.5
See related
AllianceGenome:WB:WBGene00000877
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in mitochondrion. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to several human genes including PPIA (peptidylprolyl isomerase A); PPIAL4C (peptidylprolyl isomerase A like 4C); and PPIF (peptidylprolyl isomerase F). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cyn-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
2
Sequence:
Chromosome: V; NC_003283.11 (14356076..14356822)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Choline/EthanolaminePhosphoTransferase Neighboring gene ncRNA Neighboring gene V-type proton ATPase catalytic subunit A Neighboring gene tRNA:m(4)X modification enzyme TRM13 Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and biological characterisation of the gut-associated cyclophilin B isoforms from Caenorhabditis elegans. Picken NC, et al. J Mol Biol, 2002 Sep 6. PMID 12215411
  2. Cloning and biochemical characterization of the cyclophilin homologues from the free-living nematode Caenorhabditis elegans. Page AP, et al. Biochem J, 1996 Jul 1. PMID 8694762, Free PMC Article
  3. Hepatitis B virus X protein targets the Bcl-2 protein CED-9 to induce intracellular Ca2+ increase and cell death in Caenorhabditis elegans. Geng X, et al. Proc Natl Acad Sci U S A, 2012 Nov 6. PMID 23091037, Free PMC Article
  4. Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males. Goncalves J, et al. iScience, 2020 Apr 24. PMID 32240955, Free PMC Article
  5. Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe. Pemberton TJ, et al. Comp Funct Genomics, 2005. PMID 18629211, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
Peptidyl-prolyl cis-trans isomerase 1
NP_506561.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    14356076..14356822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074160.7 → NP_506561.1  Peptidyl-prolyl cis-trans isomerase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506561.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52009
    Conserved Domains (1) summary
    cd01926
    Location:22 → 187
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52009.1

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