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atfs-1 Stress activated transcription factor atfs-1 [ Caenorhabditis elegans ]

Gene ID: 179922, updated on 2-Nov-2024

Summary

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Official Symbol
atfs-1
Official Full Name
Stress activated transcription factor atfs-1
Primary source
WormBase:WBGene00013878
Locus tag
CELE_ZC376.7
See related
AllianceGenome:WB:WBGene00013878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding activity; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial unfolded protein response; positive regulation of nematode larval development; and regulation of gene expression. Located in mitochondrial matrix and nucleus. Is expressed in intestine. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See atfs-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (14194446..14197697)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene tRNA (guanine(26)-N(2))-dimethyltransferase Neighboring gene INTegrator complex Subunit homolog Neighboring gene BTB domain-containing protein Neighboring gene Seven TM Receptor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response. Lin YF, et al. Nature, 2016 May 19. PMID 27135930, Free PMC Article
  2. The UPRmt preserves mitochondrial import to extend lifespan. Xin N, et al. J Cell Biol, 2022 Jul 4. PMID 35608535, Free PMC Article
  3. UPR(mt) scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans. Shpilka T, et al. Nat Commun, 2021 Jan 20. PMID 33473112, Free PMC Article
  4. Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt). Nargund AM, et al. Mol Cell, 2015 Apr 2. PMID 25773600, Free PMC Article
  5. Microbial Genetic Composition Tunes Host Longevity. Han B, et al. Cell, 2017 Jun 15. PMID 28622510, Free PMC Article

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans.
    Title: V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans.
  2. The UPRmt preserves mitochondrial import to extend lifespan.
    Title: The UPRmt preserves mitochondrial import to extend lifespan.
  3. Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors.
    Title: Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors.
  4. FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation.
    Title: FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation.
  5. LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria.
    Title: LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria.
  6. Caenorhabditis elegans homologue of Fam210 is required for oogenesis and reproduction.
    Title: Caenorhabditis elegans homologue of Fam210 is required for oogenesis and reproduction.
  7. ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
    Title: ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
  8. While loss of atfs-1 during adulthood does not affect lifespan in any of these strains, absence of atfs-1 during development prevents clk-1 and isp-1 worms from reaching adulthood and reduces the lifespan of nuo-6 mutants.
    Title: Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways.
  9. Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the mitochondrial unfolded protein response.
    Title: Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).
  10. The bZip transcription factor ATFS-1 mediates mitochondrial stress-induced autophagy.
    Title: Genome-wide screen identifies signaling pathways that regulate autophagy during Caenorhabditis elegans development.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mitochondrial transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nematode larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrial transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Stress activated transcription factor atfs-1
NP_001024302.1
  • Confirmed by transcript evidence
NP_001256571.1
  • Confirmed by transcript evidence
NP_506515.1
  • Confirmed by transcript evidence
NP_872160.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    14194446..14197697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_182360.9 → NP_872160.1  Stress activated transcription factor atfs-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_872160.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23272
    Conserved Domains (1) summary
    cd14692
    Location:405 → 467
    bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain

  2. NM_074114.7 → NP_506515.1  Stress activated transcription factor atfs-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506515.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E5QCH2, Q23272, Q52GY6, Q8I4B7
    Conserved Domains (1) summary
    cd14692
    Location:421 → 483
    bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain

  3. NM_001029131.6 → NP_001024302.1  Stress activated transcription factor atfs-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024302.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23272
    Conserved Domains (1) summary
    cd14692
    Location:407 → 469
    bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain

  4. NM_001269642.3 → NP_001256571.1  Stress activated transcription factor atfs-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256571.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23272
    Conserved Domains (2) summary
    cd09726
    Location:136 → 277
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein
    cd14692
    Location:214 → 276
    bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23272.1

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