end-1 GATA-type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: end-1
Official Full Name: GATA-type domain-containing protein
Primary source: WormBase:WBGene00001310
Locus tag: CELE_F58E10.2
See related: AllianceGenome:WB:WBGene00001310
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in endodermal cell fate specification and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in E lineage cell. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See end-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (13985128..13987074)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

end-1 and end-3 have each evolved into genes with unique functions during endoderm development
Title: Specific roles for the GATA transcription factors end-1 and end-3 during C. elegans E-lineage development.
PLP-1 acts as a transcriptional activator of end-1 expression that may be modulated by MAPK signaling to promote endoderm development
Title: C. elegans pur alpha, an activator of end-1, synergizes with the Wnt pathway to specify endoderm.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F58E10.2 (e-PCR)
- UniSTS:319434

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in endodermal cell fate specification	IDA Inferred from Direct Assay more info	PubMed
involved_in endodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GATA-type domain-containing protein

NP_506475.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

13985128..13987074

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074074.3 → NP_506475.1 GATA-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506475.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDN4

Conserved Domains (2) summary

COG5641
Location:80 → 221

GAT1; GATA Zn-finger-containing transcription factor [Transcription]

cd00202
Location:137 → 190

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C