T01D3.3 TIL domain-containing protein;Thyroglobulin type-1 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: T01D3.3
Official Full Name: TIL domain-containing protein;Thyroglobulin type-1 domain-containing protein
Primary source: WormBase:WBGene00011328
Locus tag: CELE_T01D3.3
See related: AllianceGenome:WB:WBGene00011328
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable metal ion binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in superoxide metabolic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See T01D3.3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 11

Sequence:: Chromosome: V; NC_003283.11 (13704271..13711091)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

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Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

T01D3.3 (e-PCR)
- UniSTS:317522

T01D3.2 (e-PCR)
- UniSTS:306075

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in superoxide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TIL domain-containing protein;Thyroglobulin type-1 domain-containing protein

NP_001360565.1

Confirmed by transcript evidence

NP_506389.2

Confirmed by transcript evidence

NP_506390.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

13704271..13711091

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073989.5 → NP_506390.1 TIL domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506390.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JL02

Conserved Domains (2) summary

pfam01826
Location:82 → 139

TIL; Trypsin Inhibitor like cysteine rich domain

cl00891
Location:675 → 770

Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...
NM_073988.8 → NP_506389.2 Thyroglobulin type-1 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506389.2

Status: REVIEWED

UniProtKB/TrEMBL

P90956

Conserved Domains (3) summary

cd00191
Location:128 → 190

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

pfam01826
Location:291 → 348

TIL; Trypsin Inhibitor like cysteine rich domain

cl00891
Location:884 → 979

Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...
NM_001373148.4 → NP_001360565.1 TIL domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WY04

Conserved Domains (2) summary

pfam01826
Location:83 → 140

TIL; Trypsin Inhibitor like cysteine rich domain

cl00891
Location:676 → 771

Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...