sde-2 Replication stress response regulator SDE2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sde-2
Official Full Name: Replication stress response regulator SDE2
Primary source: WormBase:WBGene00009996
Locus tag: CELE_F53F4.14
See related: AllianceGenome:WB:WBGene00009996
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in several processes, including DNA replication; RNA processing; and ribosome biogenesis. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human SDE2 (SDE2 telomere maintenance homolog). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See sde-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (13627613..13629831)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F53F4.14 (e-PCR)
- UniSTS:306944

STS5-211 (e-PCR)
- UniSTS:242374

F53F4.12 (e-PCR)
- UniSTS:311750

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Replication stress response regulator SDE2

NP_506378.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

13627613..13629831

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073977.7 → NP_506378.1 Replication stress response regulator SDE2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506378.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EC45

Conserved Domains (2) summary

pfam13297
Location:414 → 471

Telomere_Sde2_2; Telomere stability C-terminal

cl28922
Location:149 → 236

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold