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bir-2 Baculoviral IAP repeat-containing protein bir-2 [ Caenorhabditis elegans ]

Gene ID: 179841, updated on 9-Dec-2024

Summary

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Official Symbol
bir-2
Official Full Name
Baculoviral IAP repeat-containing protein bir-2
Primary source
WormBase:WBGene00000250
Locus tag
CELE_C50B8.2
See related
AllianceGenome:WB:WBGene00000250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within with a positive effect on germ cell proliferation. Predicted to be part of chromosome passenger complex. Predicted to be active in cytoplasm; kinetochore; and spindle midzone. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; prostate cancer; and pulmonary hypertension. Orthologous to human BIRC2 (baculoviral IAP repeat containing 2); BIRC3 (baculoviral IAP repeat containing 3); and BIRC5 (baculoviral IAP repeat containing 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See bir-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (13568850..13570030)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Ground-like domain-containing protein Neighboring gene ncRNA Neighboring gene RRM domain-containing protein Neighboring gene putative complex I intermediate-associated protein 30, mitochondrial Neighboring gene t-SNARE coiled-coil homology domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis. Fraser AG, et al. Curr Biol, 1999 Mar 25. PMID 10209096
  2. Genome-wide analysis of germ cell proliferation in C.elegans identifies VRK-1 as a key regulator of CEP-1/p53. Waters K, et al. Dev Biol, 2010 Aug 15. PMID 20599896, Free PMC Article
  3. Evasion of phagotrophic predation by protist hosts and innate immunity of metazoan hosts by Legionella pneumophila. Best AM, et al. Cell Microbiol, 2019 Jan. PMID 30370624, Free PMC Article
  4. How death shapes life during development. Baehrecke EH. Nat Rev Mol Cell Biol, 2002 Oct. PMID 12360194
  5. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Murphy CT, et al. Nature, 2003 Jul 17. PMID 12845331

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within_positive_effect germ cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
part_of chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Baculoviral IAP repeat-containing protein bir-2
NP_506362.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13568850..13570030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073961.6 → NP_506362.1  Baculoviral IAP repeat-containing protein bir-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506362.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECJ5
    Conserved Domains (1) summary
    smart00238
    Location:23 → 99
    BIR; Baculoviral inhibition of apoptosis protein repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5ECJ5.1

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