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clec-41 Cubilin [ Caenorhabditis elegans ]

Gene ID: 179797, updated on 9-Dec-2024

Summary

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Official Symbol
clec-41
Official Full Name
Cubilin
Primary source
WormBase:WBGene00007153
Locus tag
CELE_B0365.6
See related
AllianceGenome:WB:WBGene00007153
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in positive regulation of chemotaxis. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See clec-41 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (13134903..13138101, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Chondroitin proteoglycan 4 domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene Dynein Heavy Chain Neighboring gene Non-centrosomal microtubule array protein 1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis. O'Brien D, et al. Cell Rep, 2018 Jun 26. PMID 29949773, Free PMC Article
  2. The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis. Deffit SN, et al. Elife, 2017 Sep 19. PMID 28925356, Free PMC Article
  3. Effector and regulator: Diverse functions of C. elegans C-type lectin-like domain proteins. Pees B, et al. PLoS Pathog, 2021 Apr. PMID 33793670, Free PMC Article
  4. Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing. Ganem NS, et al. Cell Rep, 2019 Apr 23. PMID 31018137, Free PMC Article
  5. Specificity of the innate immune system and diversity of C-type lectin domain (CTLD) proteins in the nematode Caenorhabditis elegans. Schulenburg H, et al. Immunobiology, 2008. PMID 18406370

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in innate immune response HEP PubMed 
involved_in positive regulation of chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Cubilin
NP_506271.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13134903..13138101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073870.5 → NP_506271.1  Cubilin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506271.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P90732
    Conserved Domains (3) summary
    smart00034
    Location:163 → 281
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00042
    Location:444 → 542
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    cd00041
    Location:301 → 393
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Nucleotide Protein
Heading Accession and Version

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