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istr-1 IST1 homolog [ Caenorhabditis elegans ]

Gene ID: 179737, updated on 9-Dec-2024

Summary

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Official Symbol
istr-1
Official Full Name
IST1 homolog
Primary source
WormBase:WBGene00010736
Locus tag
CELE_K10C8.3
See related
AllianceGenome:WB:WBGene00010736
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in protein localization. Is expressed in intestine; nervous system; and pharynx. Orthologous to human IST1 (IST1 factor associated with ESCRT-III). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See istr-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (12697858..12704269)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene 3'-5' exoribonuclease parn-1 Neighboring gene Uncharacterized protein Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene F-box domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ist1 regulates ESCRT-III assembly and function during multivesicular endosome biogenesis in Caenorhabditis elegans embryos. Frankel EB, et al. Nat Commun, 2017 Nov 13. PMID 29129923, Free PMC Article
  2. The ESCRT machinery directs quality control over inner nuclear membrane architecture. Shankar R, et al. Cell Rep, 2022 Jan 18. PMID 35045304, Free PMC Article
  3. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
  4. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  5. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
IST1 homolog
NP_001122974.1
  • Partially confirmed by transcript evidence
NP_001122975.1
  • Confirmed by transcript evidence
NP_506170.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12697858..12704269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073769.7 → NP_506170.2  IST1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506170.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECX8
    Conserved Domains (1) summary
    pfam03398
    Location:13 → 180
    Ist1; Regulator of Vps4 activity in the MVB pathway

  2. NM_001129503.3 → NP_001122975.1  IST1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122975.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDV6
    Conserved Domains (1) summary
    pfam03398
    Location:13 → 180
    Ist1; Regulator of Vps4 activity in the MVB pathway

  3. NM_001129502.4 → NP_001122974.1  IST1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122974.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5Z2T4
Nucleotide Protein
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Gene LinkOut

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