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rad-50 DNA repair protein rad-50;Zinc-hook domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179678, updated on 4-Jan-2025

Summary

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Official Symbol
rad-50
Official Full Name
DNA repair protein rad-50;Zinc-hook domain-containing protein
Primary source
WormBase:WBGene00004296
Locus tag
CELE_T04H1.4
See related
AllianceGenome:WB:WBGene00004296
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable G-quadruplex DNA binding activity; double-stranded telomeric DNA binding activity; and single-stranded telomeric DNA binding activity. Predicted to be involved in chromosome organization and double-strand break repair. Predicted to be located in nucleus. Predicted to be part of Mre11 complex. Predicted to be active in condensed nuclear chromosome. Human ortholog(s) of this gene implicated in transitional cell carcinoma. Orthologous to human RAD50 (RAD50 double strand break repair protein). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See rad-50 in Genome Data Viewer
Location:
chromosome: V
Exon count:
13
Sequence:
Chromosome: V; NC_003283.11 (12245646..12251246)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Tr-type G domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene G patch domain-containing protein 11 Neighboring gene LRP X(cross)-hybridizing

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new thermosensitive smc-3 allele reveals involvement of cohesin in homologous recombination in C. elegans. Baudrimont A, et al. PLoS One, 2011. PMID 21957461, Free PMC Article
  2. Mitotic and Meiotic Functions for the SUMOylation Pathway in the Caenorhabditis elegans Germline. Reichman R, et al. Genetics, 2018 Apr. PMID 29472245, Free PMC Article
  3. The C. elegans DSB-2 protein reveals a regulatory network that controls competence for meiotic DSB formation and promotes crossover assurance. Rosu S, et al. PLoS Genet, 2013. PMID 23950729, Free PMC Article
  4. Interdependent and separable functions of Caenorhabditis elegans MRN-C complex members couple formation and repair of meiotic DSBs. Girard C, et al. Proc Natl Acad Sci U S A, 2018 May 8. PMID 29686104, Free PMC Article
  5. Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair. Hartsuiker E, et al. EMBO J, 2001 Dec 3. PMID 11726502, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables G-quadruplex DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome organization involved in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance via recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Mre11 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Mre11 complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in condensed nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA repair protein rad-50;Zinc-hook domain-containing protein
NP_001122999.1
  • Confirmed by transcript evidence
NP_506070.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12245646..12251246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129527.4 → NP_001122999.1  Zinc-hook domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122999.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5JYU5
    Conserved Domains (1) summary
    TIGR00606
    Location:16 → 1307
    rad50

  2. NM_073669.9 → NP_506070.1  DNA repair protein rad-50 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506070.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O44199, Q22177
    Conserved Domains (3) summary
    TIGR00606
    Location:2 → 1293
    rad50; rad50
    cd03240
    Location:1157 → 1279
    ABC_Rad50; ATP-binding cassette domain of Rad50
    pfam04423
    Location:646 → 694
    Rad50_zn_hook; Rad50 zinc hook motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O44199.1

Gene LinkOut

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