mif-2 MIF-like protein mif-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mif-2
Official Full Name: MIF-like protein mif-2
Primary source: WormBase:WBGene00003235
Locus tag: CELE_C52E4.2
See related: AllianceGenome:WB:WBGene00003235
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cytokine activity and phenylpyruvate tautomerase activity. Predicted to be involved in signal transduction. Predicted to be active in extracellular space. Is expressed in body wall musculature; hypodermis; and vulval muscle. Orthologous to human DDT (D-dopachrome tautomerase) and DDTL (D-dopachrome tautomerase like). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mif-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (11976777..11978459, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C52E4.3 (e-PCR)
- UniSTS:316419

C52E4.2 (e-PCR)
- UniSTS:317695

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables phenylpyruvate tautomerase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: MIF-like protein mif-2

NP_001256387.1

Partially confirmed by transcript evidence

NP_001366841.1

Confirmed by transcript evidence

NP_001367293.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11976777..11978459 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380779.1 → NP_001366841.1 MIF-like protein mif-2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18785

Conserved Domains (1) summary

pfam01187
Location:2 → 115

MIF; Macrophage migration inhibitory factor (MIF)
NM_001380778.1 → NP_001367293.1 MIF-like protein mif-2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G3MU38

Conserved Domains (1) summary

pfam01187
Location:23 → 136

MIF; Macrophage migration inhibitory factor (MIF)
NM_001269458.3 → NP_001256387.1 MIF-like protein mif-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256387.1

Status: REVIEWED

UniProtKB/TrEMBL

D6R8W7

Conserved Domains (1) summary

cl00235
Location:1 → 85

4Oxalocrotonate_Tautomerase; 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one ...