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ttll-5 Tubulin polyglutamylase ttll-5 [ Caenorhabditis elegans ]

Gene ID: 179582, updated on 2-Nov-2024

Summary

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Official Symbol
ttll-5
Official Full Name
Tubulin polyglutamylase ttll-5
Primary source
WormBase:WBGene00008331
Locus tag
CELE_C55A6.2
See related
AllianceGenome:WB:WBGene00008331
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Involved in response to hermaphrodite contact. Predicted to be active in ciliary basal body. Human ortholog(s) of this gene implicated in cone-rod dystrophy 19. Orthologous to human TTLL5 (tubulin tyrosine ligase like 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ttll-5 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (11509060..11512321)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase Neighboring gene Macro domain-containing protein;NARG2_C domain-containing protein Neighboring gene ncRNA Neighboring gene DeHydrogenases, Short chain Neighboring gene DeHydrogenases, Short chain Neighboring gene C-factor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Double mutants of TTLL glutamylase genes have little to no difference in viability or brood size. Shah P, et al. MicroPubl Biol, 2019 Aug 29. PMID 32550433, Free PMC Article
  2. Caenorhabditis elegans glutamylating enzymes function redundantly in male mating. Chawla DG, et al. Biol Open, 2016 Sep 15. PMID 27635036, Free PMC Article
  3. Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function. Power KM, et al. PLoS Genet, 2020 Oct. PMID 33064774, Free PMC Article
  4. Major sperm protein signaling promotes oocyte microtubule reorganization prior to fertilization in Caenorhabditis elegans. Harris JE, et al. Dev Biol, 2006 Nov 1. PMID 16919258
  5. In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics. Lacroix B, et al. Dev Cell, 2014 Apr 28. PMID 24780738, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in reproductive behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hermaphrodite contact IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tubulin polyglutamylase ttll-5
NP_001256331.1
  • Confirmed by transcript evidence
NP_001379188.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11509060..11512321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269402.3 → NP_001256331.1  Tubulin polyglutamylase ttll-5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256331.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E9P886, O17720
    Conserved Domains (1) summary
    pfam03133
    Location:173 → 476
    TTL; Tubulin-tyrosine ligase family

  2. NM_001392617.1 → NP_001379188.1  Tubulin polyglutamylase ttll-5 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam03133
    Location:120 → 423
    TTL; Tubulin-tyrosine ligase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9P886.1

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