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erfa-3 Eukaryotic peptide chain release factor GTP-binding subunit;GTP-eEF1A C-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179537, updated on 4-Jan-2025

Summary

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Official Symbol
erfa-3
Official Full Name
Eukaryotic peptide chain release factor GTP-binding subunit;GTP-eEF1A C-terminal domain-containing protein
Primary source
WormBase:WBGene00010405
Locus tag
CELE_H19N07.1
See related
AllianceGenome:WB:WBGene00010405
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activity and translation release factor activity. Predicted to be involved in translation. Predicted to be located in cytoplasm. Predicted to be part of translation release factor complex. Is expressed in several structures, including anal depressor muscle; excretory cell; nervous system; rectal epithelium; and reproductive system. Orthologous to human GSPT1 (G1 to S phase transition 1) and GSPT2 (G1 to S phase transition 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See erfa-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (11110100..11113091, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Cyclin-dependent kinase-like 1;Protein kinase domain-containing protein Neighboring gene LYR motif-containing protein 5 Neighboring gene pseudo Neighboring gene Ubiquitin carboxyl-terminal hydrolase 7 Neighboring gene MRG domain-containing protein Neighboring gene O-acyltransferase;diacylglycerol O-acyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Auxin-independent depletion of degron-tagged proteins by TIR1. Schiksnis E, et al. MicroPubl Biol, 2020 Jan 28. PMID 32550513, Free PMC Article
  2. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
  3. ABCE1 is a highly conserved RNA silencing suppressor. Kärblane K, et al. PLoS One, 2015. PMID 25659154, Free PMC Article
  4. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
  5. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation release factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational termination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of translation release factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Eukaryotic peptide chain release factor GTP-binding subunit;GTP-eEF1A C-terminal domain-containing protein
NP_001256292.1
  • Confirmed by transcript evidence
NP_001367276.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11110100..11113091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269363.4 → NP_001256292.1  Eukaryotic peptide chain release factor GTP-binding subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256292.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45622
    Conserved Domains (2) summary
    COG5256
    Location:105 → 532
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam06121
    Location:24 → 94
    DUF959; Domain of Unknown Function (DUF959)

  2. NM_001380755.1 → NP_001367276.1  GTP-eEF1A C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    E9P8A2
    Conserved Domains (1) summary
    cl02786
    Location:1 → 40
    Translation_factor_III; Domain III of Elongation factor (EF) Tu (EF-TU) and related proteins
Nucleotide Protein
Heading Accession and Version

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