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ceh-22 Homeobox domain-containing protein;Homeobox protein ceh-22 [ Caenorhabditis elegans ]

Gene ID: 179485, updated on 4-Jan-2025

Summary

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Official Symbol
ceh-22
Official Full Name
Homeobox domain-containing protein;Homeobox protein ceh-22
Primary source
WormBase:WBGene00000445
Locus tag
CELE_F29F11.5
See related
AllianceGenome:WB:WBGene00000445
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables sequence-specific DNA binding activity. Involved in several processes, including chordate pharyngeal muscle development; gonad morphogenesis; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including G1; gonad; neurons; pharynx; and ventral nerve cord. Used to study cancer. Orthologous to several human genes including NKX2-2 (NK2 homeobox 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ceh-22 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (10671918..10675769)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene TWiK family of potassium channels protein 12 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple enhancers contribute to expression of the NK-2 homeobox gene ceh-22 in C. elegans pharyngeal muscle. Kuchenthal CA, et al. Genesis, 2001 Dec. PMID 11783006
  2. Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities. Berger MF, et al. Nat Biotechnol, 2006 Nov. PMID 16998473, Free PMC Article
  3. Wnt signaling and CEH-22/tinman/Nkx2.5 specify a stem cell niche in C. elegans. Lam N, et al. Curr Biol, 2006 Feb 7. PMID 16461282, Free PMC Article
  4. Development of Caenorhabditis elegans pharynx, with emphasis on its nervous system. Pilon M, et al. Acta Pharmacol Sin, 2005 Apr. PMID 15780187
  5. pha-2 encodes the C. elegans ortholog of the homeodomain protein HEX and is required for the formation of the pharyngeal isthmus. Mörck C, et al. Dev Biol, 2004 Aug 15. PMID 15282157

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HTZ-1 and MYS-1 repress ceh-22 when UTX-1 removes its silencing mark, H3K27 methylation on the ceh-22 locus, thereby maintaining the fates of SGCs.
    Title: HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in C. elegans.
  2. Results suggest that pan-pharyngeal Forkhead factor PHA-4 directly initiates homeobox gene ceh-22 expression through the oligonucleotide de209.
    Title: An early pharyngeal muscle enhancer from the Caenorhabditis elegans ceh-22 gene is targeted by the Forkhead factor PHA-4.
  3. CEH-22/Nkx2.5 homeodomain transcription factor is a key regulator of distal tip cell specification.
    Title: Wnt signaling and CEH-22/tinman/Nkx2.5 specify a stem cell niche in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell fate specification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chordate pharyngeal muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonad morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Homeobox domain-containing protein;Homeobox protein ceh-22
NP_001076742.1
  • Confirmed by transcript evidence
NP_001076743.1
  • Confirmed by transcript evidence
NP_001076744.1
  • Partially confirmed by transcript evidence
NP_001343841.1
  • Partially confirmed by transcript evidence
NP_001343842.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10671918..10675769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083273.4 → NP_001076742.1  Homeobox protein ceh-22 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076742.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1EHR3, A1EHR4, P41936, Q19908
    Conserved Domains (1) summary
    pfam00046
    Location:196 → 245
    Homeobox; Homeobox domain

  2. NM_001356738.3 → NP_001343841.1  Homeobox domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1EHR3, A1EHR4, P41936, Q19908
    UniProtKB/TrEMBL
    A0A2C9C3N2
    Conserved Domains (1) summary
    pfam00046
    Location:229 → 279
    Homeobox; Homeobox domain

  3. NM_001083275.4 → NP_001076744.1  Homeobox protein ceh-22 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076744.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1EHR3, A1EHR4, P41936, Q19908
    Conserved Domains (1) summary
    pfam00046
    Location:133 → 182
    Homeobox; Homeobox domain

  4. NM_001356739.4 → NP_001343842.1  Homeobox domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C312
    Conserved Domains (1) summary
    pfam00046
    Location:110 → 160
    Homeobox; Homeobox domain

  5. NM_001083274.3 → NP_001076743.1  Homeobox protein ceh-22 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076743.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41936
    Conserved Domains (1) summary
    pfam00046
    Location:65 → 114
    Homeobox; Homeobox domain
Nucleotide Protein
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