cat-4 GTP cyclohydrolase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cat-4
Official Full Name: GTP cyclohydrolase 1
Primary source: WormBase:WBGene00000298
Locus tag: CELE_F32G8.6
See related: AllianceGenome:WB:WBGene00000298
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTP cyclohydrolase I activity. Involved in dopamine biosynthetic process from tyrosine; melanin biosynthetic process; and tetrahydrobiopterin biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including body wall musculature; dopaminergic neurons; hyp7 syncytium; intestinal cell; and serotonergic neurons. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; movement disease (multiple); sickle cell anemia; and type 2 diabetes mellitus. Orthologous to human GCH1 (GTP cyclohydrolase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cat-4 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (10564880..10566464)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F32G8.6 (e-PCR)
- UniSTS:318177

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP cyclohydrolase I activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTP cyclohydrolase I activity	IEA Inferred from Electronic Annotation more info
enables GTP cyclohydrolase I activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTP cyclohydrolase I activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables GTP cyclohydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in dopamine biosynthetic process from tyrosine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pteridine-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrobiopterin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tetrahydrobiopterin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrobiopterin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tetrahydrobiopterin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in tetrahydrofolate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GTP cyclohydrolase 1

NP_505710.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10564880..10566464

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073309.6 → NP_505710.1 GTP cyclohydrolase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505710.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19980

UniProtKB/TrEMBL

A0A0H3W5N0

Conserved Domains (1) summary

cd00642
Location:38 → 222

GTP_cyclohydro1; GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In ...