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col-12 Cuticle collagen 12 [ Caenorhabditis elegans ]

Gene ID: 179453, updated on 4-Jan-2025

Summary

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Official Symbol
col-12
Official Full Name
Cuticle collagen 12
Primary source
WormBase:WBGene00000601
Locus tag
CELE_F15H10.1
See related
AllianceGenome:WB:WBGene00000601
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be a structural constituent of cuticle. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See col-12 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (10423898..10425198, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF19 domain-containing protein Neighboring gene Cuticle collagen 13 Neighboring gene Anaphase-promoting complex subunit 10 Neighboring gene RING-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conservation of the Caenorhabditis elegans cuticle collagen gene col-12 in Caenorhabditis briggsae. Gilleard JS, et al. Gene, 1997 Jul 9. PMID 9256075
  2. Conversion of a trans-spliced C. elegans gene into a conventional gene by introduction of a splice donor site. Conrad R, et al. EMBO J, 1993 Mar. PMID 8458337, Free PMC Article
  3. Tandemly duplicated Caenorhabditis elegans collagen genes differ in their modes of splicing. Park YS, et al. J Mol Biol, 1990 Jan 20. PMID 1689778
  4. Combined extracellular matrix cross-linking activity of the peroxidase MLT-7 and the dual oxidase BLI-3 is critical for post-embryonic viability in Caenorhabditis elegans. Thein MC, et al. J Biol Chem, 2009 Jun 26. PMID 19406744, Free PMC Article
  5. Loss of SEC-23 in Caenorhabditis elegans causes defects in oogenesis, morphogenesis, and extracellular matrix secretion. Roberts B, et al. Mol Biol Cell, 2003 Nov. PMID 14551256, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural constituent of cuticle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cuticle collagen 12
NP_505678.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10423898..10425198 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073277.6 → NP_505678.1  Cuticle collagen 12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505678.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P20630
    Conserved Domains (1) summary
    smart01088
    Location:17 → 69
    Col_cuticle_N; Nematode cuticle collagen N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20630.1

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