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crm-1 Cysteine-rich motor neuron 1 protein;Cysteine-rich motor neuron 1 protein-like [ Caenorhabditis elegans ]

Gene ID: 179439, updated on 9-Dec-2024

Summary

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Official Symbol
crm-1
Official Full Name
Cysteine-rich motor neuron 1 protein;Cysteine-rich motor neuron 1 protein-like
Primary source
WormBase:WBGene00007103
Locus tag
CELE_B0024.14
See related
AllianceGenome:WB:WBGene00007103
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region and membrane. Predicted to be active in plasma membrane. Is expressed in intestine; nervous system; pharynx; and reproductive system. Orthologous to human CRIM1 (cysteine rich transmembrane BMP regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See crm-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
17
Sequence:
Chromosome: V; NC_003283.11 (10322283..10332112, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Putative pseudouridine synthase B0024.11 Neighboring gene Glucosamine 6-phosphate N-acetyltransferase Neighboring gene Polyprenal reductase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Actin-related protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of crm-1 in ionizing radiation-induced nervous system dysfunction in Caenorhabditis elegans. Long HQ, et al. Neural Regen Res, 2023 Jun. PMID 36453427, Free PMC Article
  2. Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus. Zhong Y, et al. Elife, 2017 May 2. PMID 28463106, Free PMC Article
  3. crm-1 facilitates BMP signaling to control body size in Caenorhabditis elegans. Fung WY, et al. Dev Biol, 2007 Nov 1. PMID 17869238
  4. Sex determination in the germ line. Ellis R, et al. WormBook, 2007 Mar 5. PMID 18050498, Free PMC Article
  5. A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins. Kamal M, et al. Elife, 2022 Oct 19. PMID 36259463, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cysteine-rich motor neuron 1 protein;Cysteine-rich motor neuron 1 protein-like
NP_001256210.1
  • Confirmed by transcript evidence
NP_741616.2
  • Confirmed by transcript evidence
NP_741617.2
  • Confirmed by transcript evidence
NP_741618.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10322283..10332112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171530.7 → NP_741617.2  Cysteine-rich motor neuron 1 protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741617.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEX3
    Conserved Domains (1) summary
    cl17735
    Location:541 → 592
    VWC; von Willebrand factor type C domain

  2. NM_171529.7 → NP_741616.2  Cysteine-rich motor neuron 1 protein-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741616.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EF34
    Conserved Domains (2) summary
    pfam00219
    Location:28 → 76
    IGFBP; Insulin-like growth factor binding protein
    cl17735
    Location:607 → 658
    VWC; von Willebrand factor type C domain

  3. NM_171935.7 → NP_741618.2  Cysteine-rich motor neuron 1 protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741618.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBZ2
    Conserved Domains (1) summary
    cl17735
    Location:541 → 592
    VWC; von Willebrand factor type C domain

  4. NM_001269281.4 → NP_001256210.1  Cysteine-rich motor neuron 1 protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256210.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1B6S3
    Conserved Domains (1) summary
    cl17735
    Location:516 → 567
    VWC; von Willebrand factor type C domain

RNA

  1. NR_132530.1 RNA Sequence

    Status: REVIEWED

  2. NR_132531.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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