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lys-1 Lysozyme-like protein 1 [ Caenorhabditis elegans ]

Gene ID: 179428, updated on 4-Jan-2025

Summary

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Official Symbol
lys-1
Official Full Name
Lysozyme-like protein 1
Primary source
WormBase:WBGene00003090
Locus tag
CELE_Y22F5A.4
See related
AllianceGenome:WB:WBGene00003090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and innate immune response. Located in apical part of cell and cytoplasmic vesicle. Is expressed in intestine and neurons. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See lys-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
2
Sequence:
Chromosome: V; NC_003283.11 (10277904..10279056)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Lysozyme-like protein 2 Neighboring gene Lysozyme-like protein 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tasco®: a product of Ascophyllum nodosum enhances immune response of Caenorhabditis elegans against Pseudomonas aeruginosa infection. Kandasamy S, et al. Mar Drugs, 2012 Jan. PMID 22363222, Free PMC Article
  2. Characterizing the type 6 secretion system (T6SS) of E. cloacae SBP-8 and its role in pathogenesis and bacterial competition. Khan S, et al. Microb Pathog, 2023 Oct. PMID 37536636
  3. Paeoniflorin increases the survival of Pseudomonas aeruginosa infected Caenorhabditis elegans at the immunosuppression stage by activating PMK-1, BAR-1, and EGL-1 signals. Zhang L, et al. Arch Pharm Res, 2023 Jul. PMID 37535304
  4. Elucidating the pathogenic potential of Enterobacter cloacae SBP-8 using Caenorhabditis elegans as a model host. Khan S, et al. Microb Pathog, 2020 Nov. PMID 32798671
  5. Antimicrobial proteins in the response to graphene oxide in Caenorhabditis elegans. Ren M, et al. Nanotoxicology, 2017 May. PMID 28490217

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response HEP PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to stress IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Lysozyme-like protein 1
NP_505642.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10277904..10279056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073241.7 → NP_505642.1  Lysozyme-like protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505642.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62415
    Conserved Domains (1) summary
    cd06416
    Location:60 → 262
    GH25_Lys1-like; Lys-1 is a lysozyme encoded by the Caenorhabditis elegans lys-1 gene. This gene is one of a several lysozyme genes upregulated upon infection by the Gram-negative bacterial pathogen Serratia marcescens. Lys-1 contains a glycosyl hydrolase family 25 ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O62415.1

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