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rmd-2 TPR_REGION domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179391, updated on 2-Nov-2024

Summary

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Official Symbol
rmd-2
Official Full Name
TPR_REGION domain-containing protein
Primary source
WormBase:WBGene00007786
Locus tag
CELE_C27H6.4
See related
AllianceGenome:WB:WBGene00007786
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable microtubule binding activity. Predicted to be located in membrane. Predicted to be active in mitochondrion; mitotic spindle pole; and spindle microtubule. Orthologous to human RMDN2 (regulator of microtubule dynamics 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rmd-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (9983919..9986277, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene RuvB-like 1 Neighboring gene Schlafen-like protein 1 Neighboring gene Mitochondrial genome maintenance exonuclease 1 Neighboring gene MYG1 protein C27H6.8 Neighboring gene Piwi domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Paternal mitochondria from an rmd-2, rmd-3, rmd-6 triple mutant are properly positioned in the C. elegans zygote. Juanico IY, et al. MicroPubl Biol, 2021. PMID 34296068, Free PMC Article
  2. Global Proteomic Response of Caenorhabditis elegans Against PemK(Sa) Toxin. Mir DA, et al. Front Cell Infect Microbiol, 2019. PMID 31214513, Free PMC Article
  3. An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans. Meissner B, et al. PLoS Genet, 2009 Jun. PMID 19557190, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TPR_REGION domain-containing protein
NP_001122866.1
  • Confirmed by transcript evidence
NP_741608.2
  • Confirmed by transcript evidence
NP_741609.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9983919..9986277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171523.6 → NP_741609.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741609.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P90762
    Conserved Domains (3) summary
    PRK11447
    Location:205 → 257
    PRK11447; cellulose synthase subunit BcsC; Provisional
    TIGR02917
    Location:140 → 262
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:222 → 250
    TPR; TPR repeat [structural motif]

  2. NM_171522.7 → NP_741608.2  TPR_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741608.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQB5
    Conserved Domains (3) summary
    PRK11447
    Location:311 → 363
    PRK11447; cellulose synthase subunit BcsC; Provisional
    TIGR02917
    Location:246 → 368
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:273 → 323
    TPR; TPR repeat [structural motif]

  3. NM_001129394.5 → NP_001122866.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122866.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B2D6P1
    Conserved Domains (3) summary
    PRK11447
    Location:158 → 210
    PRK11447; cellulose synthase subunit BcsC; Provisional
    TIGR02917
    Location:93 → 215
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:175 → 203
    TPR; TPR repeat [structural motif]
Nucleotide Protein
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