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xbx-6 Protein lifeguard 1-like [ Caenorhabditis elegans ]

Gene ID: 179361, updated on 9-Dec-2024

Summary

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Official Symbol
xbx-6
Official Full Name
Protein lifeguard 1-like
Primary source
WormBase:WBGene00009580
Locus tag
CELE_F40F9.1
See related
AllianceGenome:WB:WBGene00009580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium channel activity. Predicted to be involved in apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of neuron apoptotic process. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in several structures, including alimentary muscle; nervous system; pharynx; reproductive system; and tail. Orthologous to several human genes including GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See xbx-6 in Genome Data Viewer
Location:
chromosome: V
Exon count:
10
Sequence:
Chromosome: V; NC_003283.11 (9703055..9707835)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene RNA_ligase domain-containing protein Neighboring gene Protein her-1 Neighboring gene Transmembrane BAX inhibitor motif-containing protein 4 Neighboring gene tRNA wybutosine-synthesizing protein 2 homolog Neighboring gene ncRNA Neighboring gene PDZ domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fas-apoptotic inhibitory molecule 2 localizes to the lysosome and facilitates autophagosome-lysosome fusion through the LC3 interaction region motif-dependent interaction with LC3. Hong CJ, et al. FASEB J, 2020 Jan. PMID 31914609
  2. Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Sarin S, et al. Nat Methods, 2008 Oct. PMID 18677319, Free PMC Article
  3. Analysis of xbx genes in C. elegans. Efimenko E, et al. Development, 2005 Apr. PMID 15790967
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein lifeguard 1-like
NP_001379309.1
  • Confirmed by transcript evidence
NP_741597.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9703055..9707835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392582.1 → NP_001379309.1  Protein lifeguard 1-like [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQ55
    Conserved Domains (1) summary
    cd10428
    Location:74 → 293
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

  2. NM_171511.8 → NP_741597.1  Protein lifeguard 1-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741597.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQ56
    Conserved Domains (1) summary
    cd10428
    Location:74 → 293
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

RNA

  1. NR_069217.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

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