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srsx-34 G-protein coupled receptors family 1 profile domain-containing protein;MFS domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179281, updated on 9-Dec-2024

Summary

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Official Symbol
srsx-34
Official Full Name
G-protein coupled receptors family 1 profile domain-containing protein;MFS domain-containing protein
Primary source
WormBase:WBGene00016093
Locus tag
CELE_C25E10.3
See related
AllianceGenome:WB:WBGene00016093
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in lysosomal membrane. Is expressed in neurons. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Orthologous to human MFSD8 (major facilitator superfamily domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See srsx-34 in Genome Data Viewer
Location:
chromosome: V
Exon count:
16
Sequence:
Chromosome: V; NC_003283.11 (9035985..9040350)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MFS domain-containing protein Neighboring gene MFS domain-containing protein Neighboring gene CYtochrome P450 family Neighboring gene Nuclear Hormone Receptor family Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy. Sewell AK, et al. iScience, 2022 May 20. PMID 35479415, Free PMC Article
  2. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G-protein coupled receptors family 1 profile domain-containing protein;MFS domain-containing protein
NP_001367564.1
  • Partially confirmed by transcript evidence
NP_505341.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9035985..9040350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072940.6 → NP_505341.1  MFS domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505341.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZ09
    Conserved Domains (2) summary
    cl00339
    Location:49 → 90
    SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...
    cl21472
    Location:36 → 229
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  2. NM_001380720.1 → NP_001367564.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZ10
    Conserved Domains (2) summary
    cd14964
    Location:9 → 34
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17 → 269
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. NR_145827.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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