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H14N18.4 Gamma-glutamyltranspeptidase 1 [ Caenorhabditis elegans ]

Gene ID: 179271, updated on 4-Jan-2025

Summary

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Official Symbol
H14N18.4
Official Full Name
Gamma-glutamyltranspeptidase 1
Primary source
WormBase:WBGene00019204
Locus tag
CELE_H14N18.4
See related
AllianceGenome:WB:WBGene00019204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glutathione hydrolase activity. Predicted to be involved in glutathione catabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to human GGT1 (gamma-glutamyltransferase 1); GGT2P (gamma-glutamyltransferase 2, pseudogene); and GGT3P (gamma-glutamyltransferase 3 pseudogene). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See H14N18.4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
12
Sequence:
Chromosome: V; NC_003283.11 (8923845..8928978, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transthyretin-like family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF2726 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Gamma-glutamyltranspeptidase 1
NP_001343850.1
  • Confirmed by transcript evidence
NP_001343851.1
  • Confirmed by transcript evidence
NP_001367934.1
  • Confirmed by transcript evidence
NP_001370776.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8923845..8928978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356716.3 → NP_001343850.1  Gamma-glutamyltranspeptidase 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C326
    Conserved Domains (1) summary
    pfam01019
    Location:120 → 636
    G_glu_transpept; Gamma-glutamyltranspeptidase

  2. NM_001380718.2 → NP_001367934.1  Gamma-glutamyltranspeptidase 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WIT0
    Conserved Domains (1) summary
    pfam01019
    Location:90 → 614
    G_glu_transpept; Gamma-glutamyltranspeptidase

  3. NM_001383361.1 → NP_001370776.1  Gamma-glutamyltranspeptidase 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0B7
    Conserved Domains (1) summary
    pfam01019
    Location:120 → 644
    G_glu_transpept; Gamma-glutamyltranspeptidase

  4. NM_001356718.4 → NP_001343851.1  Gamma-glutamyltranspeptidase 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C375
    Conserved Domains (1) summary
    pfam01019
    Location:90 → 606
    G_glu_transpept; Gamma-glutamyltranspeptidase
Nucleotide Protein
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