hyls-1 Centriolar and ciliogenesis-associated protein hyls-1;Hydrolethalus syndrome protein 1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hyls-1
Official Full Name: Centriolar and ciliogenesis-associated protein hyls-1;Hydrolethalus syndrome protein 1 homolog
Primary source: WormBase:WBGene00015466
Locus tag: CELE_C05C8.9
See related: AllianceGenome:WB:WBGene00015466
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in cilium assembly and foraging behavior. Located in centriole and non-motile cilium. Is expressed in amphid neurons; inner labial neurons; and outer labial neurons. Used to study hydrolethalus syndrome. Human ortholog(s) of this gene implicated in hydrolethalus syndrome 1. Orthologous to human HYLS1 (HYLS1 centriolar and ciliogenesis associated). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See hyls-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (7237381..7239659)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data support an important role for HYLS-1 and Transition fibres in establishment of the ciliary gate and underline the importance of selective protein entry for cilia assembly.
Title: The hydrolethalus syndrome protein HYLS-1 regulates formation of the ciliary gate.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C05C8.1 (e-PCR)
- UniSTS:318995

STS5-161 (e-PCR)
- UniSTS:242321

C05C8.6 (e-PCR)
- UniSTS:308466

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in foraging behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in non-motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Centriolar and ciliogenesis-associated protein hyls-1;Hydrolethalus syndrome protein 1 homolog

NP_001367430.1

Confirmed by transcript evidence

NP_504840.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

7237381..7239659

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072439.7 → NP_504840.1 Centriolar and ciliogenesis-associated protein hyls-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504840.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95X94

Conserved Domains (1) summary

pfam15311
Location:195 → 250

HYLS1_C; Hydrolethalus syndrome protein 1 C-terminus
NM_001380690.2 → NP_001367430.1 Hydrolethalus syndrome protein 1 homolog [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2KYG1