scd-2 ALK tyrosine kinase receptor homolog scd-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: scd-2
Official Full Name: ALK tyrosine kinase receptor homolog scd-2
Primary source: WormBase:WBGene00004740
Locus tag: CELE_T10H9.2
See related: AllianceGenome:WB:WBGene00004740
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in dauer larval development; sensory perception of chemical stimulus; and sensory processing. Predicted to be located in plasma membrane. Is expressed in body wall musculature; intestine; and nervous system. Orthologous to human ALK (ALK receptor tyrosine kinase) and LTK (leukocyte receptor tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See scd-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 22

Sequence:: Chromosome: V; NC_003283.11 (6633225..6639665)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In C. elegans, after mapping and sequencing, lrn-2 was found to be allelic to the gene, scd-2. scd-2-mediated associative learning and sensory integration operate in separate neurons as separate processes.
Title: A Receptor Tyrosine Kinase Plays Separate Roles in Sensory Integration and Associative Learning in C. elegans.
SCD-2 and GCY-28 regulate sensory integration by modulating the activity of interneurons. Proper sensory integration is important for proper behavioral choices.
Title: Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase, GCY-28, and a receptor tyrosine kinase, SCD-2, in AIA interneurons of Caenorhabditis elegans.
SCD-2 encodes the nematode anaplastic lymphoma kinase (ALK) homolog, a proto-oncogene receptor tyrosine kinase.
Title: C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta signaling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T10H9.2 (e-PCR)
- UniSTS:310798

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of chemical stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory perception of chemical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory processing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ALK tyrosine kinase receptor homolog scd-2

NP_504685.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

6633225..6639665

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072284.4 → NP_504685.3 ALK tyrosine kinase receptor homolog scd-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504685.3

Status: REVIEWED

UniProtKB/Swiss-Prot

O76411

Conserved Domains (4) summary

smart00219
Location:976 → 1241

TyrKc; Tyrosine kinase, catalytic domain

cd00112
Location:305 → 338

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam12810
Location:590 → 805

Gly_rich; Glycine rich protein

cl21453
Location:969 → 1239

PKc_like; Protein Kinases, catalytic domain