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hpo-19 NADH-cytochrome b5 reductase [ Caenorhabditis elegans ]

Gene ID: 179029, updated on 4-Jan-2025

Summary

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Official Symbol
hpo-19
Official Full Name
NADH-cytochrome b5 reductase
Primary source
WormBase:WBGene00020268
Locus tag
CELE_T05H4.5
See related
AllianceGenome:WB:WBGene00020268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable FAD binding activity. Predicted to be located in membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in breast cancer and methemoglobinemia. Orthologous to human CYB5R1 (cytochrome b5 reductase 1); CYB5R2 (cytochrome b5 reductase 2); and CYB5R3 (cytochrome b5 reductase 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See hpo-19 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (6436645..6437884)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Gastrulation defective protein 1 Neighboring gene Eukaryotic peptide chain release factor subunit 1 Neighboring gene NADH-cytochrome b5 reductase Neighboring gene F-box associated domain-containing protein;FBA_2 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans. Zhang Y, et al. Biochim Biophys Acta, 2016 Apr. PMID 26806391
  2. Cytochrome b5 reductase: the roles of the recessive congenital methemoglobinemia mutants P144L, L148P, and R159*. Davis CA, et al. Arch Biochem Biophys, 2004 Nov 15. PMID 15488472
  3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cytochrome b5 reductase HPO-19/T05H4.4 is required for desaturation to biosynthesize PUFAs in C. elegans.
    Title: The cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytochrome-b5 reductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NADH-cytochrome b5 reductase
NP_504638.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6436645..6437884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072237.7 → NP_504638.1  NADH-cytochrome b5 reductase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504638.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16521
    Conserved Domains (2) summary
    cd06183
    Location:53 → 309
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    PTZ00319
    Location:9 → 309
    PTZ00319; NADH-cytochrome B5 reductase; Provisional
Nucleotide Protein
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