aps-1 AP complex subunit sigma [Caenorhabditis elegans] - Gene

Summary

Official Symbol: aps-1
Official Full Name: AP complex subunit sigma
Primary source: WormBase:WBGene00000159
Locus tag: CELE_F29G9.3
See related: AllianceGenome:WB:WBGene00000159
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in apical protein localization. Predicted to be located in Golgi apparatus; clathrin-coated pit; and cytoplasmic vesicle. Predicted to be part of AP-1 adaptor complex. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in MEDNIK syndrome; psoriasis 15; and syndromic X-linked intellectual disability 5. Orthologous to several human genes including AP1S1 (adaptor related protein complex 1 subunit sigma 1) and AP1S2 (adaptor related protein complex 1 subunit sigma 2). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in apical protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of AP-1 adaptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_001379652.1

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