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rpt-2 putative 26S proteasome regulatory subunit 4 [ Caenorhabditis elegans ]

Gene ID: 178988, updated on 2-Nov-2024

Summary

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Official Symbol
rpt-2
Official Full Name
putative 26S proteasome regulatory subunit 4
Primary source
WormBase:WBGene00004502
Locus tag
CELE_F29G9.5
See related
AllianceGenome:WB:WBGene00004502
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables ubiquitin protein ligase binding activity. Involved in negative regulation of gene expression. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome regulatory particle, base subcomplex. Is expressed in body wall musculature; head; intestine; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss. Orthologous to human PSMC1 (proteasome 26S subunit, ATPase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rpt-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (6016059..6017669, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Transcription factor fos-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AP complex subunit sigma

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans. Landsverk ML, et al. J Cell Biol, 2007 Apr 23. PMID 17438072, Free PMC Article
  2. UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans. Wilson KJ, et al. Mol Biol Cell, 2012 Jul. PMID 22621901, Free PMC Article
  3. A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress. Springer W, et al. Hum Mol Genet, 2005 Nov 15. PMID 16204351
  4. A Hemidesmosome-to-Cytoplasm Translocation of Small Heat Shock Proteins Provides Immediate Protection against Heat Stress. Fu R, et al. Cell Rep, 2020 Nov 24. PMID 33238119
  5. RbAp46/48(LIN-53) Is Required for Holocentromere Assembly in Caenorhabditis elegans. Lee BC, et al. Cell Rep, 2016 Mar 1. PMID 26904949

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables proteasome-activating activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proteasomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative 26S proteasome regulatory subunit 4
NP_504558.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6016059..6017669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072157.8 → NP_504558.1  putative 26S proteasome regulatory subunit 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504558.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16368
    Conserved Domains (3) summary
    PTZ00361
    Location:1 → 443
    PTZ00361; 26 proteosome regulatory subunit 4-like protein; Provisional
    pfam00004
    Location:225 → 358
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam16450
    Location:112 → 179
    Prot_ATP_ID_OB; Proteasomal ATPase OB/ID domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O16368.1

Gene LinkOut

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