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dhs-16 3beta-hydroxysteroid dehydrogenase dhs-16 [ Caenorhabditis elegans ]

Gene ID: 178983, updated on 9-Dec-2024

Summary

Official Symbol
dhs-16
Official Full Name
3beta-hydroxysteroid dehydrogenase dhs-16
Primary source
WormBase:WBGene00000979
Locus tag
CELE_C10F3.2
See related
AllianceGenome:WB:WBGene00000979
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables steroid dehydrogenase activity. Involved in steroid catabolic process. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in head neurons; hypodermis; tail neurons; and terminal bulb. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 13; fundus albipunctatus; and night blindness. Orthologous to several human genes including DHRS9 (dehydrogenase/reductase 9); HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6); and RDH5 (retinol dehydrogenase 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See dhs-16 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (5983745..5985509)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene adenylate cyclase Neighboring gene ncRNA Neighboring gene DUF4789 domain-containing protein Neighboring gene Alpha-(1,6)-fucosyltransferase Neighboring gene ncRNA

Pathways from PubChem

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables oxidoreductase activity  
enables oxidoreductase activity  
enables steroid dehydrogenase activity PubMed 
Process Evidence Code Pubs
involved_in cholesterol metabolic process  
involved_in steroid catabolic process PubMed 
involved_in steroid metabolic process  
Component Evidence Code Pubs
located_in membrane  

General protein information

Preferred Names
3beta-hydroxysteroid dehydrogenase dhs-16
NP_504554.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5983745..5985509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072153.8 → NP_504554.1  3beta-hydroxysteroid dehydrogenase dhs-16 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504554.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16881
    Conserved Domains (2) summary
    pfam00106
    Location:33 → 228
    adh_short; short chain dehydrogenase
    cl21454
    Location:33 → 319
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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