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mut-14 RNA helicase [ Caenorhabditis elegans ]

Gene ID: 178952, updated on 4-Jan-2025

Summary

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Official Symbol
mut-14
Official Full Name
RNA helicase
Primary source
WormBase:WBGene00003507
Locus tag
CELE_C14C11.6
See related
AllianceGenome:WB:WBGene00003507
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA helicase activity and mRNA binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Located in mutator focus. Is expressed in germ cell and germ line. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mut-14 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (5658713..5660704, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CUB-like domain-containing protein Neighboring gene beta-N-acetylhexosaminidase Neighboring gene YDG domain-containing protein Neighboring gene Movement protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Low impact of germline transposition on the rate of mildly deleterious mutation in Caenorhabditis elegans. Bégin M, et al. Genetics, 2006 Dec. PMID 17057249, Free PMC Article
  2. Transposable elements, mutational correlations, and population divergence in Caenorhabditis elegans. Bégin M, et al. Evolution, 2007 May. PMID 17492961
  3. RNAi protects the Caenorhabditis elegans germline against transposition. Vastenhouw NL, et al. Trends Genet, 2004 Jul. PMID 15219396
  4. mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Zhang C, et al. Proc Natl Acad Sci U S A, 2011 Jan 25. PMID 21245313, Free PMC Article
  5. Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi. Sijen T, et al. Nature, 2003 Nov 20. PMID 14628056

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation.
    Title: MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gamete generation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P granule IEA
Inferred from Electronic Annotation
more info
  
located_in mutator focus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA helicase
NP_504490.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5658713..5660704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072089.6 → NP_504490.1  RNA helicase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504490.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17978
    Conserved Domains (3) summary
    COG0513
    Location:101 → 523
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00270
    Location:117 → 297
    DEAD; DEAD/DEAH box helicase
    pfam00271
    Location:352 → 471
    Helicase_C; Helicase conserved C-terminal domain
Nucleotide Protein
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