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unc-62 Homeobox domain-containing protein;Homeobox protein unc-62 [ Caenorhabditis elegans ]

Gene ID: 178845, updated on 4-Jan-2025

Summary

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Official Symbol
unc-62
Official Full Name
Homeobox domain-containing protein;Homeobox protein unc-62
Primary source
WormBase:WBGene00006796
Locus tag
CELE_T28F12.2
See related
AllianceGenome:WB:WBGene00006796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate specification; muscle cell differentiation; and regulation of gene expression. Acts upstream of or within lipid homeostasis. Located in chromatin and nucleus. Is expressed in several structures, including body wall musculature; hypodermis; neurons; reproductive system; and vulval precursor cell. Used to study leukemia and restless legs syndrome. Human ortholog(s) of this gene implicated in alcohol dependence; cleft palate, cardiac defects, and intellectual disabillity; learning disability; open-angle glaucoma; and orofacial cleft (multiple). Orthologous to several human genes including MEIS1 (Meis homeobox 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See unc-62 in Genome Data Viewer
Location:
chromosome: V
Exon count:
12
Sequence:
Chromosome: V; NC_003283.11 (4497463..4511447)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene NADP-dependent oxidoreductase domain-containing protein Neighboring gene Transmembrane protein Neighboring gene Son of sevenless homolog Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of unc-62 expression pattern in C. elegans embryonic AWC neurons. Hsieh YW, et al. MicroPubl Biol, 2022. PMID 35198862, Free PMC Article
  2. Roles of the developmental regulator unc-62/Homothorax in limiting longevity in Caenorhabditis elegans. Van Nostrand EL, et al. PLoS Genet, 2013. PMID 23468654, Free PMC Article
  3. Integrative analysis of C. elegans modENCODE ChIP-seq data sets to infer gene regulatory interactions. Van Nostrand EL, et al. Genome Res, 2013 Jun. PMID 23531767, Free PMC Article
  4. MEIS1 and Restless Legs Syndrome: A Comprehensive Review. Sarayloo F, et al. Front Neurol, 2019. PMID 31551905, Free PMC Article
  5. Maternal Caffeine Intake Disrupts Eggshell Integrity and Retards Larval Development by Reducing Yolk Production in a Caenorhabditis elegans Model. Min H, et al. Nutrients, 2020 May 7. PMID 32392893, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synergistic roles of homeodomain proteins UNC-62 homothorax and MLS-2 HMX/NKX in the specification of olfactory neurons in Caenorhabditis elegans.
    Title: Synergistic roles of homeodomain proteins UNC-62 homothorax and MLS-2 HMX/NKX in the specification of olfactory neurons in Caenorhabditis elegans.
  2. Different Meis/UNC-62 isoforms act through specific regions of the unc-55 promoter. UNC-62 isoforms differentially regulate the mRNA and protein expression of UNC-55.
    Title: Meis/UNC-62 isoform dependent regulation of CoupTF-II/UNC-55 and GABAergic motor neuron subtype differentiation.
  3. These results illustrate how unc-62 regulation of intestinal gene expression is responsible for limiting lifespan during the normal aging process.
    Title: Roles of the developmental regulator unc-62/Homothorax in limiting longevity in Caenorhabditis elegans.
  4. UNC-62 plays essential roles in regulating cell fate specification & differentiation in the mesodermal M lineage. UNC-62 functions together with CEH-20 in regulating these processes.
    Title: Two Hox cofactors, the Meis/Hth homolog UNC-62 and the Pbx/Exd homolog CEH-20, function together during C. elegans postembryonic mesodermal development.
  5. Functions independently of lin-39 in vulva development.
    Title: The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryonic pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in eye development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mesodermal cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mesodermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Homeobox domain-containing protein;Homeobox protein unc-62
NP_001024169.1
  • Confirmed by transcript evidence
NP_001024170.1
  • Confirmed by transcript evidence
NP_001024173.1
  • Confirmed by transcript evidence
NP_001024175.1
  • Confirmed by transcript evidence
NP_001300207.1
  • Confirmed by transcript evidence
NP_001367923.1
  • Confirmed by transcript evidence
NP_001367924.1
  • Confirmed by transcript evidence
NP_001370772.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    4497463..4511447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380635.2 → NP_001367923.1  Homeobox protein unc-62 [Caenorhabditis elegans]

    Status: REVIEWED

  2. NM_001028998.5 → NP_001024169.1  Homeobox protein unc-62 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024169.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5TKQ8, Q8MXU6, Q8MXU7, Q8WRQ5, Q8WRQ6, Q9N5D5, Q9N5D6
    Conserved Domains (2) summary
    pfam05920
    Location:410 → 449
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:133 → 218
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  3. NM_001380634.1 → NP_001367924.1  Homeobox protein unc-62 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    pfam05920
    Location:406 → 445
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:133 → 219
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  4. NM_001383298.1 → NP_001370772.1  Homeobox protein unc-62 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam05920
    Location:3 → 38
    Homeobox_KN; Homeobox KN domain

  5. NM_001028999.5 → NP_001024170.1  Homeobox protein unc-62 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024170.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N5D6
    Conserved Domains (2) summary
    pfam05920
    Location:373 → 412
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  6. NM_001029002.4 → NP_001024173.1  Homeobox protein unc-62 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024173.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N5D6
    Conserved Domains (2) summary
    pfam05920
    Location:369 → 408
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  7. NM_001313278.3 → NP_001300207.1  Homeobox domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ASC5
    Conserved Domains (2) summary
    pfam05920
    Location:332 → 371
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:59 → 145
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  8. NM_001029004.5 → NP_001024175.1  Homeobox protein unc-62 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024175.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N5D6
    Conserved Domains (2) summary
    pfam05920
    Location:336 → 375
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:59 → 144
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N5D6.1

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