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gmpr-1 GMP reductase [ Caenorhabditis elegans ]

Gene ID: 178834, updated on 9-Dec-2024

Summary

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Official Symbol
gmpr-1
Official Full Name
GMP reductase
Primary source
WormBase:WBGene00017984
Locus tag
CELE_F32D1.5
See related
AllianceGenome:WB:WBGene00017984
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GMP reductase activity and metal ion binding activity. Predicted to be involved in purine nucleobase metabolic process and purine nucleotide metabolic process. Predicted to be part of GMP reductase complex. Orthologous to several human genes including GMPR (guanosine monophosphate reductase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gmpr-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (4369353..4371383, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Ground-like domain-containing protein Neighboring gene Activin_recp domain-containing protein Neighboring gene Pre-mRNA polyadenylation factor Fip1 domain-containing protein Neighboring gene Negative Effect on Gut development Neighboring gene Protein lilliputian

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi. van Haaften G, et al. Curr Biol, 2006 Jul 11. PMID 16824923
  2. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
  3. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  4. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
  5. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GMP reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleobase metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GMP reductase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GMP reductase
NP_001317809.1
  • Confirmed by transcript evidence
NP_504202.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    4369353..4371383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071801.9 → NP_504202.1  GMP reductase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504202.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16294
    Conserved Domains (2) summary
    TIGR01305
    Location:3 → 345
    GMP_reduct_1; guanosine monophosphate reductase, eukaryotic
    cd00381
    Location:10 → 337
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...

  2. NM_001330859.3 → NP_001317809.1  GMP reductase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A168H4W1
    Conserved Domains (1) summary
    TIGR01305
    Location:1 → 76
    GMP_reduct_1; guanosine monophosphate reductase, eukaryotic
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O16294.1

Gene LinkOut

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