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nlp-27 Neuropeptide-Like Protein [ Caenorhabditis elegans ]

Gene ID: 178806, updated on 4-Jan-2025

Summary

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Official Symbol
nlp-27
Official Full Name
Neuropeptide-Like Protein
Primary source
WormBase:WBGene00003765
Locus tag
CELE_B0213.2
See related
AllianceGenome:WB:WBGene00003765
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in defense response to Gram-negative bacterium. Predicted to be located in membrane. Is expressed in ASI; head neurons; hypodermis; intestine; and spermatheca. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nlp-27 in Genome Data Viewer
Location:
chromosome: V
Exon count:
2
Sequence:
Chromosome: V; NC_003283.11 (3989378..3989770)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene QWGYGGY-amide Neighboring gene QWGYGGY-amide Neighboring gene Usp domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans neuropeptide NLP-27 enhances neurodegeneration and paralysis in an opioid-like manner during fungal infection. Pop M, et al. iScience, 2024 Apr 19. PMID 38784855, Free PMC Article
  2. Nematode Peptides with Host-Directed Anti-inflammatory Activity Rescue Caenorhabditis elegans from a Burkholderia pseudomallei Infection. Lim MP, et al. Front Microbiol, 2016. PMID 27672387, Free PMC Article
  3. TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM. Couillault C, et al. Nat Immunol, 2004 May. PMID 15048112
  4. Anti-fungal innate immunity in C. elegans is enhanced by evolutionary diversification of antimicrobial peptides. Pujol N, et al. PLoS Pathog, 2008 Jul 18. PMID 18636113, Free PMC Article
  5. Identification of neuropeptide-like protein gene families in Caenorhabditiselegans and other species. Nathoo AN, et al. Proc Natl Acad Sci U S A, 2001 Nov 20. PMID 11717458, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Neuropeptide-Like Protein
NP_504111.1
  • Product from WormBase gene class nlp;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    3989378..3989770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071710.9 → NP_504111.1  Neuropeptide-Like Protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504111.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44666
Nucleotide Protein
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