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srp-3 Serpin domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178672, updated on 2-Nov-2024

Summary

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Official Symbol
srp-3
Official Full Name
Serpin domain-containing protein
Primary source
WormBase:WBGene00005644
Locus tag
CELE_Y32G9A.4
See related
AllianceGenome:WB:WBGene00005644
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable peptidase activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in body wall musculature; intestine; and muscle cell. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); liver disease (multiple); lung disease (multiple); and retinal vascular disease (multiple). Orthologous to several human genes including SERPINI1 (serpin family I member 1) and SERPINI2 (serpin family I member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See srp-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (1908842..1910692)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans muscle specific serpin, SRP-3, neutralizes chymotrypsin-like serine peptidases. Pak SC, et al. Biochemistry, 2006 Apr 11. PMID 16584183, Free PMC Article
  2. Selective conservation of the RSL-encoding, proteinase inhibitory-type, clade L serpins in Caenorhabditis species. Luke CJ, et al. Front Biosci, 2006 Jan 1. PMID 16146754
  3. SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins. Pak SC, et al. J Biol Chem, 2004 Apr 9. PMID 14739286
  4. Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates. Xu X, et al. BMC Genomics, 2006 Oct 4. PMID 17020603, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Serpin domain-containing protein
NP_503528.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    1908842..1910692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071127.5 → NP_503528.2  Serpin domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503528.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECY2
    Conserved Domains (1) summary
    cd19581
    Location:5 → 360
    serpinL_nematode; serpin family L, serpin family proteins from nematodes
Nucleotide Protein
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Gene LinkOut

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