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rga-4 Rho-GAP domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178629, updated on 9-Dec-2024

Summary

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Official Symbol
rga-4
Official Full Name
Rho-GAP domain-containing protein
Primary source
WormBase:WBGene00022286
Locus tag
CELE_Y75B7AL.4
See related
AllianceGenome:WB:WBGene00022286
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables GTPase activator activity. Involved in asymmetric protein localization involved in cell fate determination; cortical actin cytoskeleton organization; and regulation of actin filament-based process. Is expressed in embryonic cell and germ line. Orthologous to human ARHGAP11A (Rho GTPase activating protein 11A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rga-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (1373120..1383256, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene C2 domain-containing protein Neighboring gene ncRNA Neighboring gene DUF148 domain-containing protein Neighboring gene C2 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved RhoGAP limits M phase contractility and coordinates with microtubule asters to confine RhoA during cytokinesis. Zanin E, et al. Dev Cell, 2013 Sep 16. PMID 24012485, Free PMC Article
  2. Functions of the novel RhoGAP proteins RGA-3 and RGA-4 in the germ line and in the early embryo of C. elegans. Schmutz C, et al. Development, 2007 Oct. PMID 17728351
  3. The Rho GTPase-activating proteins RGA-3 and RGA-4 are required to set the initial size of PAR domains in Caenorhabditis elegans one-cell embryos. Schonegg S, et al. Proc Natl Acad Sci U S A, 2007 Sep 18. PMID 17848508, Free PMC Article
  4. The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis. Zhang D, et al. Elife, 2015 Aug 7. PMID 26252513, Free PMC Article
  5. The TAO kinase KIN-18 regulates contractility and establishment of polarity in the C. elegans embryo. Spiga FM, et al. Dev Biol, 2013 Jan 1. PMID 23064028

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identified two redundant GTPase activating proteins (GAPs) - RGA-3 and RGA-4 - that regulate Rho GTPase function at the plasma membrane in early embryos
    Title: Functions of the novel RhoGAP proteins RGA-3 and RGA-4 in the germ line and in the early embryo of C. elegans.
  2. we identify the GTPase-activating proteins (GAPs) RGA-4, which regulate the activity of the small GTPase RHO-1.
    Title: The Rho GTPase-activating proteins RGA-3 and RGA-4 are required to set the initial size of PAR domains in Caenorhabditis elegans one-cell embryos.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in asymmetric protein localization involved in cell fate determination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of actin filament-based process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of actin filament-based process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rho-GAP domain-containing protein
NP_001041201.1
  • Confirmed by transcript evidence
NP_001041202.1
  • Confirmed by transcript evidence
NP_001300288.1
  • Partially confirmed by transcript evidence
NP_001300289.1
  • Confirmed by transcript evidence
NP_001300290.1
  • Confirmed by transcript evidence
NP_001300291.1
  • Confirmed by transcript evidence
NP_001300292.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    1373120..1383256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047736.4 → NP_001041201.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041201.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q965S4
    Conserved Domains (1) summary
    smart00324
    Location:63 → 230
    RhoGAP; GTPase-activator protein for Rho-like GTPases

  2. NM_001313359.5 → NP_001300288.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AW57
    Conserved Domains (1) summary
    smart00324
    Location:63 → 230
    RhoGAP; GTPase-activator protein for Rho-like GTPases

  3. NM_001047737.3 → NP_001041202.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041202.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZS7
    Conserved Domains (1) summary
    smart00324
    Location:63 → 235
    RhoGAP; GTPase-activator protein for Rho-like GTPases

  4. NM_001313361.3 → NP_001300290.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AT49
    Conserved Domains (1) summary
    smart00324
    Location:1 → 150
    RhoGAP; GTPase-activator protein for Rho-like GTPases

  5. NM_001313360.3 → NP_001300289.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AYE4
    Conserved Domains (1) summary
    smart00324
    Location:1 → 150
    RhoGAP; GTPase-activator protein for Rho-like GTPases

  6. NM_001313363.3 → NP_001300292.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ASJ8

  7. NM_001313362.3 → NP_001300291.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AVE9
Nucleotide Protein
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