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W07B8.4 Peptidase C1A papain C-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178611, updated on 2-Nov-2024

Summary

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Official Symbol
W07B8.4
Official Full Name
Peptidase C1A papain C-terminal domain-containing protein
Primary source
WormBase:WBGene00021072
Locus tag
CELE_W07B8.4
See related
AllianceGenome:WB:WBGene00021072
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See W07B8.4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (1130112..1131930, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Saccharopine dehydrogenase-like C-terminal domain-containing protein;Sacchrp_dh_NADP domain-containing protein Neighboring gene Expressed conserved protein;PB1 domain-containing protein Neighboring gene ncRNA Neighboring gene Cathepsin B-like cysteine proteinase 5 Neighboring gene Peptidase C1A papain C-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Peptidase C1A papain C-terminal domain-containing protein
NP_001300213.1
  • Partially confirmed by transcript evidence
NP_503382.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    1130112..1131930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070981.7 → NP_503382.1  Peptidase C1A papain C-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503382.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16288
    Conserved Domains (1) summary
    cd02620
    Location:74 → 327
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

  2. NM_001313284.3 → NP_001300213.1  Peptidase C1A papain C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AVX9
    Conserved Domains (1) summary
    cl23744
    Location:4 → 132
    Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...
Nucleotide Protein
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