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fmo-5 Flavin-containing monooxygenase [ Caenorhabditis elegans ]

Gene ID: 178596, updated on 9-Dec-2024

Summary

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Official Symbol
fmo-5
Official Full Name
Flavin-containing monooxygenase
Primary source
WormBase:WBGene00001480
Locus tag
CELE_H24K24.5
See related
AllianceGenome:WB:WBGene00001480
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable monooxygenase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in excretory gland cell; intestine; and ventral nerve cord. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to several human genes including FMO2 (flavin containing dimethylaniline monoxygenase 2); FMO3 (flavin containing dimethylaniline monoxygenase 3); and FMO4 (flavin containing dimethylaniline monoxygenase 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fmo-5 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (899304..903665, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein Neighboring gene Zinc metalloproteinase nas-32 Neighboring gene RRM domain-containing protein;tRNA (uracil(54)-C(5))-methyltransferase Neighboring gene Alcohol dehydrogenase class-3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The fmo genes of Caenorhabditis elegans and C. briggsae: characterisation, gene expression and comparative genomic analysis. Petalcorin MI, et al. Gene, 2005 Feb 14. PMID 15716098
  2. The PH/MyTH4/FERM molecule MAX-1 inhibits UNC-5 activity in the regulation of VD growth cone protrusion in Caenorhabditis elegans. Mahadik SS, et al. Genetics, 2022 May 5. PMID 35348689, Free PMC Article
  3. Flavin monooxygenases regulate Caenorhabditis elegans axon guidance and growth cone protrusion with UNC-6/Netrin signaling and Rac GTPases. Gujar MR, et al. PLoS Genet, 2017 Aug. PMID 28859089, Free PMC Article
  4. Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. Kwon JY, et al. Genomics, 2004 Apr. PMID 15028283
  5. Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans. Lewis JA, et al. BMC Genomics, 2009 Apr 29. PMID 19402892, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables N,N-dimethylaniline monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD(P)H oxidase H2O2-forming activity IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables hypotaurine monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Flavin-containing monooxygenase
NP_001300132.1
  • Confirmed by transcript evidence
NP_503352.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    899304..903665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070951.5 → NP_503352.1  Flavin-containing monooxygenase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503352.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ED43
    Conserved Domains (2) summary
    pfam00743
    Location:4 → 511
    FMO-like; Flavin-binding monooxygenase-like
    cl21454
    Location:8 → 222
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_001313203.3 → NP_001300132.1  Flavin-containing monooxygenase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AS63
    Conserved Domains (1) summary
    pfam00743
    Location:7 → 173
    FMO-like; Flavin-binding monooxygenase-like
Nucleotide Protein
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