srp-2 Serpin domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Official Symbol: srp-2
Official Full Name: Serpin domain-containing protein
Primary source: WormBase:WBGene00005643
Locus tag: CELE_C05E4.1
See related: AllianceGenome:WB:WBGene00005643
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cysteine-type endopeptidase inhibitor activity and serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. Is expressed in several structures, including anal sphincter muscle; cuticle; eggshell; epithelial cell; and phasmid neurons. Used to study familial encephalopathy with neuroserpin inclusion bodies. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); lung disease (multiple); neurodegenerative disease (multiple); and retinal vascular disease (multiple). Orthologous to several human genes including SERPINI1 (serpin family I member 1) and SERPINI2 (serpin family I member 2). [provided by Alliance of Genome Resources, Jan 2025]
NEW: Try the new Gene table
Try the new Transcript table

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

SRP-2 is neither an ortholog nor a functional homolog of neuroserpin.
Title: The aggregation-prone intracellular serpin SRP-2 fails to transit the ER in Caenorhabditis elegans.
SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode
Title: SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

NP_503318.1

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain