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lec-12 Galectin;Galectin domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178548, updated on 4-Jan-2025

Summary

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Official Symbol
lec-12
Official Full Name
Galectin;Galectin domain-containing protein
Primary source
WormBase:WBGene00017080
Locus tag
CELE_DC2.3
See related
AllianceGenome:WB:WBGene00017080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable carbohydrate binding activity and galactoside binding activity. Predicted to be located in membrane. Orthologous to human LGALS4 (galectin 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See lec-12 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (204382..209755)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene AT-rich interactive domain-containing protein arid-1 Neighboring gene Trafficking protein particle complex subunit Neighboring gene DeHydrogenases, Short chain Neighboring gene Serpentine Receptor, class H

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The DC2.3 gene in Caenorhabditis elegans encodes a galectin that recognizes the galactoseβ1→4fucose disaccharide unit. Nemoto-Sasaki Y, et al. Biol Pharm Bull, 2011. PMID 21963509
  2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables galactoside binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Galectin;Galectin domain-containing protein
NP_001023758.2
  • Partially confirmed by transcript evidence
NP_001023759.2
  • Confirmed by transcript evidence
NP_001300065.1
  • Partially confirmed by transcript evidence
NP_001300066.1
  • Confirmed by transcript evidence
NP_001300067.1
  • Confirmed by transcript evidence
NP_001300068.1
  • Confirmed by transcript evidence
NP_001300069.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    204382..209755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028588.6 → NP_001023759.2  Galectin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023759.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5ZR27
    Conserved Domains (2) summary
    smart00908
    Location:208 → 337
    Gal-bind_lectin; Galactoside-binding lectin
    cd00070
    Location:21 → 167
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

  2. NM_001028587.4 → NP_001023758.2  Galectin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023758.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZJ9
    Conserved Domains (1) summary
    cd00070
    Location:21 → 167
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

  3. NM_001313137.3 → NP_001300066.1  Galectin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUS0
    Conserved Domains (2) summary
    smart00908
    Location:168 → 297
    Gal-bind_lectin; Galactoside-binding lectin
    cd00070
    Location:8 → 127
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

  4. NM_001313136.3 → NP_001300065.1  Galectin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ASC7
    Conserved Domains (1) summary
    cd00070
    Location:8 → 127
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

  5. NM_001313139.3 → NP_001300068.1  Galectin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AVE8
    Conserved Domains (2) summary
    smart00908
    Location:69 → 198
    Gal-bind_lectin; Galactoside-binding lectin
    cl00071
    Location:2 → 30
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

  6. NM_001313138.1 → NP_001300067.1  Galectin domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARW6
    Conserved Domains (1) summary
    cl00071
    Location:2 → 30
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

  7. NM_001313140.3 → NP_001300069.1  Galectin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AXP2
    Conserved Domains (1) summary
    smart00908
    Location:11 → 90
    Gal-bind_lectin; Galactoside-binding lectin
Nucleotide Protein
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