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eelo-2 Peptidase M3A/M3B catalytic domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178501, updated on 2-Nov-2024

Summary

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Official Symbol
eelo-2
Official Full Name
Peptidase M3A/M3B catalytic domain-containing protein
Primary source
WormBase:WBGene00013997
Locus tag
CELE_ZK550.3
See related
AllianceGenome:WB:WBGene00013997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human THOP1 (thimet oligopeptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See eelo-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
17
Sequence:
Chromosome: IV; NC_003282.8 (17250131..17254964)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene HTH TFE/IIEalpha-type domain-containing protein Neighboring gene phytanoyl-CoA dioxygenase Neighboring gene ncRNA Neighboring gene putative phytanoyl-CoA dioxygenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases. Kirstein-Miles J, et al. Dev Dyn, 2010 May. PMID 20419784, Free PMC Article
  2. β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans. Walser M, et al. PLoS Genet, 2017 Jan. PMID 28135265, Free PMC Article
  3. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
  4. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  5. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
NOT involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Peptidase M3A/M3B catalytic domain-containing protein
NP_503059.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    17250131..17254964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070658.8 → NP_503059.2  Peptidase M3A/M3B catalytic domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503059.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62512
    Conserved Domains (1) summary
    pfam01432
    Location:298 → 756
    Peptidase_M3; Peptidase family M3
Nucleotide Protein
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