U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

skr-12 Skp1-related protein [ Caenorhabditis elegans ]

Gene ID: 178496, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
skr-12
Official Full Name
Skp1-related protein
Primary source
WormBase:WBGene00004818
Locus tag
CELE_C52D10.6
See related
AllianceGenome:WB:WBGene00004818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. Is expressed in ASIL; ASIR; intestine; and pharynx. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See skr-12 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_003282.8 (17167274..17167792)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Skp1-related protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. An Expanded Role for the RFX Transcription Factor DAF-19, with Dual Functions in Ciliated and Nonciliated Neurons. De Stasio EA, et al. Genetics, 2018 Mar. PMID 29301909, Free PMC Article
  2. DRE-1: an evolutionarily conserved F box protein that regulates C. elegans developmental age. Fielenbach N, et al. Dev Cell, 2007 Mar. PMID 17336909
  3. Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Ghazi A, et al. Proc Natl Acad Sci U S A, 2007 Apr 3. PMID 17392428, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Skp1-related protein
NP_001367151.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    17167274..17167792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380569.1 → NP_001367151.1  Skp1-related protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGD5, Q8WSZ7
    Conserved Domains (2) summary
    cd18322
    Location:14 → 138
    BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
    pfam01466
    Location:124 → 161
    Skp1; Skp1 family, dimerization domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools