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bca-2 Carbonic anhydrase [ Caenorhabditis elegans ]

Gene ID: 178484, updated on 4-Jan-2025

Summary

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Official Symbol
bca-2
Official Full Name
Carbonic anhydrase
Primary source
WormBase:WBGene00013805
Locus tag
CELE_Y116A8C.28
See related
AllianceGenome:WB:WBGene00013805
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables carbonate dehydratase activity. Involved in one-carbon metabolic process. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See bca-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (17096386..17100248, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2;DUF3800 domain-containing protein Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Neighboring gene Branchpoint-bridging protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular and biochemical analysis of the beta class carbonic anhydrases in Caenorhabditis elegans. Fasseas MK, et al. Mol Biol Rep, 2010 Jul. PMID 19816790
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carbonate dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in one-carbon metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
Carbonic anhydrase
NP_001255922.1
  • Partially confirmed by transcript evidence
NP_001255923.1
  • Confirmed by transcript evidence
NP_001299975.1
  • Confirmed by transcript evidence
NP_001370216.1
  • Confirmed by transcript evidence
NP_001379318.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    17096386..17100248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392454.1 → NP_001379318.1  Carbonic anhydrase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I102
    Conserved Domains (1) summary
    cl00391
    Location:10 → 112
    beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...

  2. NM_001383263.2 → NP_001370216.1  Carbonic anhydrase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2YS41
    Conserved Domains (1) summary
    cl00391
    Location:10 → 232
    beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...

  3. NM_001268993.5 → NP_001255922.1  Carbonic anhydrase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255922.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3NQA9
    Conserved Domains (1) summary
    cl00391
    Location:10 → 277
    beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...

  4. NM_001313046.3 → NP_001299975.1  Carbonic anhydrase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARK9
    Conserved Domains (1) summary
    cl00391
    Location:1 → 173
    beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...

  5. NM_001268994.3 → NP_001255923.1  Carbonic anhydrase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255923.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3NQB0
Nucleotide Protein
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