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dpy-4 Nematode cuticle collagen N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178414, updated on 9-Dec-2024

Summary

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Official Symbol
dpy-4
Official Full Name
Nematode cuticle collagen N-terminal domain-containing protein
Primary source
WormBase:WBGene00001066
Locus tag
CELE_Y41E3.2
See related
AllianceGenome:WB:WBGene00001066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be a structural constituent of cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be located in membrane. Predicted to be part of collagen trimer. Human ortholog(s) of this gene implicated in several diseases, including atherosclerosis; brain small vessel disease 2; osteochondrodysplasia (multiple); porencephaly; and uterine fibroid. Orthologous to human COL4A2 (collagen type IV alpha 2 chain); COL9A1 (collagen type IX alpha 1 chain); and COL27A1 (collagen type XXVII alpha 1 chain). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dpy-4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (14985543..14986784, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene GB1/RHD3-type G domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The origin of footprints of the Tc1 transposon of Caenorhabditis elegans. Plasterk RH. EMBO J, 1991 Jul. PMID 1646714, Free PMC Article
  2. Formaldehyde mutagenesis in the nematode Caenorhabditis elegans. Moerman DG, et al. Mutat Res, 1981 Feb. PMID 7207485
  3. A new member of the ras superfamily, the rac1 homologue from Caenorhabditis elegans. Cloning and sequence analysis of cDNA, pattern of developmental expression, and biochemical characterization of the protein. Chen W, et al. J Biol Chem, 1993 Jan 5. PMID 7677998
  4. Control of cell fate in C. elegans by a GLP-1 peptide consisting primarily of ankyrin repeats. Roehl H, et al. Nature, 1993 Aug 12. PMID 8350921
  5. Mutations in the sup-38 gene of Caenorhabditis elegans suppress muscle-attachment defects in unc-52 mutants. Gilchrist EJ, et al. Genetics, 1992 Oct. PMID 1427037, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural constituent of cuticle IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nematode cuticle collagen N-terminal domain-containing protein
NP_502808.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    14985543..14986784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070407.4 → NP_502808.1  Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502808.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62432
    Conserved Domains (2) summary
    pfam01391
    Location:226 → 269
    Collagen; Collagen triple helix repeat (20 copies)
    smart01088
    Location:12 → 64
    Col_cuticle_N; Nematode cuticle collagen N-terminal domain
Nucleotide Protein
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