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melo-1 RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178401, updated on 23-Jan-2025

Summary

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Official Symbol
melo-1
Official Full Name
RRM domain-containing protein
Primary source
WormBase:WBGene00013307
Locus tag
CELE_Y57G11C.9
See related
AllianceGenome:WB:WBGene00013307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Predicted to be involved in negative regulation of gene expression, epigenetic and protein localization to heterochromatin. Predicted to be active in nucleoplasm. Orthologous to human PPHLN1 (periphilin 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See melo-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (14787031..14790843)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cyclin N-terminal domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Neuropeptide-Like Protein Neighboring gene Rab GDP dissociation inhibitor Neighboring gene Ubiquinone biosynthesis O-methyltransferase, mitochondrial Neighboring gene Protein BRICK1 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CRISPR-mediated genetic interaction profiling identifies RNA binding proteins controlling metazoan fitness. Norris AD, et al. Elife, 2017 Jul 18. PMID 28718764, Free PMC Article
  2. Automated profiling of gene function during embryonic development. Green RA, et al. Cell, 2024 Jun 6. PMID 38759650,
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression, epigenetic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RRM domain-containing protein
NP_001263816.1
  • Confirmed by transcript evidence
NP_001379285.1
  • Partially confirmed by transcript evidence
NP_502785.2
  • Confirmed by transcript evidence
NP_502786.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    14787031..14790843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392443.1 → NP_001379285.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95Q12

  2. NM_070384.6 → NP_502785.2  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502785.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U202
    Conserved Domains (1) summary
    cd00590
    Location:52 → 123
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_070385.7 → NP_502786.1  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502786.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U203
    Conserved Domains (1) summary
    cd00590
    Location:52 → 123
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. NM_001276887.3 → NP_001263816.1  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263816.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8FDY2
Nucleotide Protein
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