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sqrd-1 FAD/NAD(P)-binding domain-containing protein;Pyr_redox_2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178374, updated on 9-Dec-2024

Summary

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Official Symbol
sqrd-1
Official Full Name
FAD/NAD(P)-binding domain-containing protein;Pyr_redox_2 domain-containing protein
Primary source
WormBase:WBGene00008538
Locus tag
CELE_F02H6.5
See related
AllianceGenome:WB:WBGene00008538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable FAD binding activity and sulfide:quinone oxidoreductase activity. Predicted to be involved in sulfide oxidation, using sulfide:quinone oxidoreductase. Predicted to be active in mitochondrion. Orthologous to human SQOR (sulfide quinone oxidoreductase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sqrd-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (14219871..14224440)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GEI-8, a homologue of vertebrate nuclear receptor corepressor NCoR/SMRT, regulates gonad development and neuronal functions in Caenorhabditis elegans. Mikoláš P, et al. PLoS One, 2013. PMID 23484030, Free PMC Article
  2. Mitochondrial Sulfide Quinone Oxidoreductase Prevents Activation of the Unfolded Protein Response in Hydrogen Sulfide. Horsman JW, et al. J Biol Chem, 2016 Mar 4. PMID 26677221, Free PMC Article
  3. Lifespan and healthspan benefits of exogenous H(2)S in C. elegans are independent from effects downstream of eat-2 mutation. Ng LT, et al. NPJ Aging Mech Dis, 2020. PMID 32566245, Free PMC Article
  4. The response of Caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide. Budde MW, et al. Genetics, 2011 Oct. PMID 21840852, Free PMC Article
  5. Thiol reductive stress activates the hypoxia response pathway. Ravi, et al. EMBO J, 2023 Nov 15. PMID 37902464, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ER and mitochondrial stress responses are activated in sqrd-1 mutant animals exposed to H2S, but not in wild-type animals.
    Title: Mitochondrial Sulfide Quinone Oxidoreductase Prevents Activation of the Unfolded Protein Response in Hydrogen Sulfide.
  2. Data indicate that genes sqrd-1, ethe-1, cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide and hydrogen cyanide.
    Title: The response of Caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfide:quinone oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in sulfide oxidation, using sulfide:quinone oxidoreductase IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
FAD/NAD(P)-binding domain-containing protein;Pyr_redox_2 domain-containing protein
NP_001255798.1
  • Confirmed by transcript evidence
NP_001255799.1
  • Confirmed by transcript evidence
NP_001255800.1
  • Confirmed by transcript evidence
NP_001293941.1
  • Confirmed by transcript evidence
NP_001294231.1
  • Confirmed by transcript evidence
NP_001294232.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    14219871..14224440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268869.4 → NP_001255798.1  FAD/NAD(P)-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255798.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62133
    Conserved Domains (1) summary
    COG0446
    Location:28 → 377
    FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

  2. NM_001268870.4 → NP_001255799.1  FAD/NAD(P)-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255799.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6KRP5
    Conserved Domains (1) summary
    COG0446
    Location:23 → 328
    FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

  3. NM_001307012.3 → NP_001293941.1  Pyr_redox_2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293941.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ADY3
    Conserved Domains (1) summary
    COG0446
    Location:20 → 316
    FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

  4. NM_001268871.3 → NP_001255800.1  FAD/NAD(P)-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255800.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6KRP6
    Conserved Domains (1) summary
    COG0446
    Location:20 → 267
    FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

  5. NM_001307303.3 → NP_001294232.1  Pyr_redox_2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294232.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M1ZJU1
    Conserved Domains (1) summary
    COG0446
    Location:67 → 183
    FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

  6. NM_001307302.3 → NP_001294231.1  Pyr_redox_2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294231.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M1ZJZ0
    Conserved Domains (1) summary
    COG0446
    Location:3 → 134
    FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]
Nucleotide Protein
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