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ent-4 Equilibrative nucleoside transporter 1 [ Caenorhabditis elegans ]

Gene ID: 178339, updated on 2-Nov-2024

Summary

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Official Symbol
ent-4
Official Full Name
Equilibrative nucleoside transporter 1
Primary source
WormBase:WBGene00008123
Locus tag
CELE_C47A4.2
See related
AllianceGenome:WB:WBGene00008123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable nucleoside transmembrane transporter activity. Predicted to be involved in nucleoside transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in histiocytosis-lymphadenopathy plus syndrome. Orthologous to several human genes including SLC29A2 (solute carrier family 29 member 2) and SLC29A3 (solute carrier family 29 member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ent-4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
10
Sequence:
Chromosome: IV; NC_003282.8 (13726930..13732829)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glial regulators of ions and solutes required for specific chemosensory functions in Caenorhabditis elegans. Wang L, et al. iScience, 2022 Dec 22. PMID 36567707, Free PMC Article
  2. A systems biology analysis of reproductive toxicity effects induced by multigenerational exposure to ionizing radiation in C. elegans. Guédon R, et al. Ecotoxicol Environ Saf, 2021 Dec 1. PMID 34544019
  3. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
  4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables nucleoside transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nucleoside transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Equilibrative nucleoside transporter 1
NP_001023068.1
  • Confirmed by transcript evidence
NP_001023069.1
  • Confirmed by transcript evidence
NP_001040927.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13726930..13732829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027897.4 → NP_001023068.1  Equilibrative nucleoside transporter 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023068.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JKL2
    Conserved Domains (1) summary
    cl15430
    Location:54 → 442
    Nucleoside_tran; Nucleoside transporter

  2. NM_001027898.3 → NP_001023069.1  Equilibrative nucleoside transporter 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023069.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3L8
    Conserved Domains (1) summary
    cl15430
    Location:60 → 448
    Nucleoside_tran; Nucleoside transporter

  3. NM_001047462.4 → NP_001040927.1  Equilibrative nucleoside transporter 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040927.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2EEN3
    Conserved Domains (1) summary
    cl15430
    Location:1 → 380
    Nucleoside_tran; Nucleoside transporter
Nucleotide Protein
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