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lsm-3 U6 snRNA-associated Sm-like protein LSm3 [ Caenorhabditis elegans ]

Gene ID: 178303, updated on 9-Dec-2024

Summary

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Official Symbol
lsm-3
Official Full Name
U6 snRNA-associated Sm-like protein LSm3
Primary source
WormBase:WBGene00003077
Locus tag
CELE_Y62E10A.12
See related
AllianceGenome:WB:WBGene00003077
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Predicted to be involved in P-body assembly and mRNA splicing, via spliceosome. Located in P-body. Orthologous to human LSM3 (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lsm-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (13387469..13389143)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ras-related protein Rab-10 Neighboring gene Tim44-like domain-containing protein Neighboring gene Mediator complex subunit 9 Neighboring gene Guanine nucleotide exchange factor MSS4 Neighboring gene Phosphoserine phosphatase Neighboring gene MEiosis-to-MItosis transition associated

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cytoplasmic LSM-1 protein regulates stress responses through the insulin/IGF-1 signaling pathway in Caenorhabditis elegans. Cornes E, et al. RNA, 2015 Sep. PMID 26150554, Free PMC Article
  2. Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos. Gallo CM, et al. Dev Biol, 2008 Nov 1. PMID 18692039
  3. The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling. Rüegger S, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25753661, Free PMC Article
  4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that LSM-1 and LSM-3 are not essential for Caenorhabditis elegans viability but contribute to the regulation of development, reproduction, and motility.
    Title: Cytoplasmic LSM-1 protein regulates stress responses through the insulin/IGF-1 signaling pathway in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in P-body assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Lsm1-7-Pat1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IEA
Inferred from Electronic Annotation
more info
  
part_of U6 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U6 snRNP IEA
Inferred from Electronic Annotation
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U6 snRNA-associated Sm-like protein LSm3
NP_001293891.1
  • Confirmed by transcript evidence
NP_502579.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13387469..13389143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070178.7 → NP_502579.1  U6 snRNA-associated Sm-like protein LSm3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502579.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U1W8
    Conserved Domains (1) summary
    cd01730
    Location:16 → 97
    LSm3; Like-Sm protein 3

  2. NM_001306962.1 → NP_001293891.1  U6 snRNA-associated Sm-like protein LSm3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293891.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AIX6
    Conserved Domains (1) summary
    cl00259
    Location:1 → 14
    Sm_like; Sm and related proteins
Nucleotide Protein
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