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lin-54 CRC domain-containing protein;Protein lin-54 [ Caenorhabditis elegans ]

Gene ID: 178280, updated on 4-Jan-2025

Summary

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Official Symbol
lin-54
Official Full Name
CRC domain-containing protein;Protein lin-54
Primary source
WormBase:WBGene00003037
Locus tag
CELE_JC8.6
See related
AllianceGenome:WB:WBGene00003037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in autosome and condensed nuclear chromosome. Part of DRM complex. Is expressed in several structures, including pharynx and vulva. Orthologous to human LIN54 (lin-54 DREAM MuvB core complex component) and TESMIN (testis expressed metallothionein like protein). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See lin-54 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (13241044..13243401)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SAC3/GANP/THP3 conserved domain-containing protein Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein uL11 Neighboring gene CMP/dCMP-type deaminase domain-containing protein Neighboring gene Cytochrome c oxidase assembly protein COX11, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A gene recommender algorithm to identify coexpressed genes in C. elegans. Owen AB, et al. Genome Res, 2003 Aug. PMID 12902378, Free PMC Article
  2. The conserved multi-functional nuclear protein dss-1/Sem1 is required for C9orf72-associated ALS/FTD dipeptide toxicity. Puleo N, et al. MicroPubl Biol, 2020 Jun 2. PMID 32550521, Free PMC Article
  3. Opposing activities of DRM and MES-4 tune gene expression and X-chromosome repression in Caenorhabditis elegans germ cells. Tabuchi TM, et al. G3 (Bethesda), 2014 Jan 10. PMID 24281426, Free PMC Article
  4. New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans. Thomas JH, et al. Genetics, 2003 May. PMID 12750327, Free PMC Article
  5. Wnt Signaling Drives Ectopic Gene Expression and Larval Arrest in the Absence of the Caenorhabditis elegans DREAM Repressor Complex. Cherian JR, et al. G3 (Bethesda), 2020 Feb 6. PMID 31843805, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of DRM complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in autosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CRC domain-containing protein;Protein lin-54
NP_001360500.1
  • Confirmed by transcript evidence
NP_001360501.1
  • Confirmed by transcript evidence
NP_502544.1
  • Confirmed by transcript evidence
NP_502545.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13241044..13243401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070144.6 → NP_502545.1  Protein lin-54 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95QD7
    Conserved Domains (1) summary
    pfam03638
    Location:244 → 281
    TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

  2. NM_001372945.2 → NP_001360500.1  CRC domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WWG3
    Conserved Domains (1) summary
    pfam03638
    Location:248 → 282
    TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

  3. NM_001372946.3 → NP_001360501.1  CRC domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WX88
    Conserved Domains (1) summary
    pfam03638
    Location:248 → 282
    TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

  4. NM_070143.4 → NP_502544.1  Protein lin-54 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62295, Q95QD7
    Conserved Domains (1) summary
    pfam03638
    Location:250 → 287
    TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95QD7.1

Gene LinkOut

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