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pin-2 LIM domain-containing protein pin-2 [ Caenorhabditis elegans ]

Gene ID: 178234, updated on 4-Jan-2025

Summary

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Official Symbol
pin-2
Official Full Name
LIM domain-containing protein pin-2
Primary source
WormBase:WBGene00004030
Locus tag
CELE_F07C6.1
See related
AllianceGenome:WB:WBGene00004030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including cell-cell junction organization; positive regulation of integrin-mediated signaling pathway; and positive regulation of substrate adhesion-dependent cell spreading. Located in cytoplasm; nucleus; and varicosity. Is expressed in PVT. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pin-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (12793847..12796164)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene CcmD family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cytohesin Ubiquitin Protein Inducing domain-containing protein;FERM domain-containing protein Neighboring gene Bax inhibitor-1 family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. Hobert O, et al. J Cell Biol, 1999 Jan 11. PMID 9885243, Free PMC Article
  2. Differential functions of the C. elegans FGF receptor in axon outgrowth and maintenance of axon position. Bülow HE, et al. Neuron, 2004 May 13. PMID 15134634
  3. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in varicosity IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
LIM domain-containing protein pin-2
NP_001255672.1
  • Confirmed by transcript evidence
NP_001255673.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12793847..12796164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268743.3 → NP_001255672.1  LIM domain-containing protein pin-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255672.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H9G2V0, H9G2V1, Q19157
    Conserved Domains (3) summary
    cd09331
    Location:21 → 79
    LIM1_PINCH; The first LIM domain of protein PINCH
    cd09334
    Location:200 → 256
    LIM4_PINCH; The fourth LIM domain of protein PINCH
    cl02475
    Location:264 → 315
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_001268744.3 → NP_001255673.1  LIM domain-containing protein pin-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255673.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19157
    Conserved Domains (1) summary
    cl02475
    Location:1 → 41
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19157.2

Gene LinkOut

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